Endothelial failure and rejection in recipients of corneas from the same donor
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ..
OBJECTIVE: To determine whether patients who receive corneas from the same donor have similar risks of endothelial failure and rejection.
METHODS AND ANALYSIS: Patients with Fuchs endothelial dystrophy (FED) and pseudophakic bullous keratopathy (PBK) who received their first corneal transplant between 1999 and 2016 were analysed. Patients receiving corneas from donors who donated both corneas for the same indication were defined as 'paired'. Gray's test was used to compare the cumulative incidence of endothelial failure and rejection within 5 years post-transplant for 'paired' and 'unpaired' groups. Cox regression models were fitted to determine whether there was an association between recorded donor characteristics (endothelial cell density (ECD), age and sex and endothelial graft failure and rejection.
RESULTS: 10 838 patients were analysed of whom 1536 (14%) were paired. The unpaired group comprised 1837 (69%) recipients of single corneal donors and 7465 (69%) donors who donated both corneas for another indication. ECD was lower for unpaired single cornea donors (p<0.01). There was no significant difference in endothelial graft failure or rejection between paired and unpaired groups for FED (p=0.37, p=0.99) or PBK (p=0.88, p=0.28) nor for donor ECD, age, sex and paired donation after adjusting for transplant factors (across all models p>0.16 for ECD, p>0.32 for donor age, p>0.14 for sex match and p>0.17 for the donor effect).
CONCLUSION: The absence of a significant difference in graft outcome for corneal transplants for FED and PBK between paired and unpaired donors may reflect a homogeneous donor pool in the UK.
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CommentIn: BMJ Open Ophthalmol. 2022 Aug;7(1):. - PMID 36161834 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
BMJ open ophthalmology - 7(2022), 1 vom: 03. Aug. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Downward, Lewis [VerfasserIn] |
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Date Completed 28.09.2022 Date Revised 30.09.2022 published: Print CommentIn: BMJ Open Ophthalmol. 2022 Aug;7(1):. - PMID 36161834 Citation Status MEDLINE |
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| doi: |
10.1136/bmjophth-2021-000965 |
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| 245 | 1 | 0 | |a Endothelial failure and rejection in recipients of corneas from the same donor |
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| 500 | |a Date Completed 28.09.2022 | ||
| 500 | |a Date Revised 30.09.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: BMJ Open Ophthalmol. 2022 Aug;7(1):. - PMID 36161834 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. | ||
| 520 | |a OBJECTIVE: To determine whether patients who receive corneas from the same donor have similar risks of endothelial failure and rejection | ||
| 520 | |a METHODS AND ANALYSIS: Patients with Fuchs endothelial dystrophy (FED) and pseudophakic bullous keratopathy (PBK) who received their first corneal transplant between 1999 and 2016 were analysed. Patients receiving corneas from donors who donated both corneas for the same indication were defined as 'paired'. Gray's test was used to compare the cumulative incidence of endothelial failure and rejection within 5 years post-transplant for 'paired' and 'unpaired' groups. Cox regression models were fitted to determine whether there was an association between recorded donor characteristics (endothelial cell density (ECD), age and sex and endothelial graft failure and rejection | ||
| 520 | |a RESULTS: 10 838 patients were analysed of whom 1536 (14%) were paired. The unpaired group comprised 1837 (69%) recipients of single corneal donors and 7465 (69%) donors who donated both corneas for another indication. ECD was lower for unpaired single cornea donors (p<0.01). There was no significant difference in endothelial graft failure or rejection between paired and unpaired groups for FED (p=0.37, p=0.99) or PBK (p=0.88, p=0.28) nor for donor ECD, age, sex and paired donation after adjusting for transplant factors (across all models p>0.16 for ECD, p>0.32 for donor age, p>0.14 for sex match and p>0.17 for the donor effect) | ||
| 520 | |a CONCLUSION: The absence of a significant difference in graft outcome for corneal transplants for FED and PBK between paired and unpaired donors may reflect a homogeneous donor pool in the UK | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cornea | |
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| 700 | 1 | |a Romano, Vito |e verfasserin |4 aut | |
| 700 | 1 | |a Curnow, Elinor |e verfasserin |4 aut | |
| 700 | 1 | |a Kaye, Stephen B |e verfasserin |4 aut | |
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