Circ-OMAC drives metastasis in oral squamous cell carcinoma
© 2022 Wiley Periodicals LLC..
OBJECTIVES: Accumulating studies have proved that the circular RNAs (circRNAs) play vital roles in human cancers. However, few circRNAs have been elucidated with lymph node metastasis. This study demonstrated that circ-oral cancer metastasis-associated circRNA (circ-OMAC) is required to regulate the oral squamous cell carcinoma (OSCC) metastasis.
MATERIALS AND METHODS: The circ-OMAC were detected by circRNA-sequencing and further verified by in situ hybridization (ISH). The role of circ-OMAC was assessed by transwell assay and wound healing assay. Mechanistically, circ-OMAC regulated OSCC metastasis by initiating the epithelial-to-mesenchymal transition (EMT) signaling pathway.
RESULTS: Our findings suggested that circ-OMAC was aberrantly elevated in the metastatic lymph nodes as compared to primary OSCC tissues. OSCC patients with high levels of circ-OMAC were prone to a poor prognosis. By developing functional assays, we confirmed that circ-OMAC promotes metastasis of OSCC cells via initiation of EMT pathways.
CONCLUSIONS: We provide new insights whereby Circ-OMAC as an oncogene is a potential therapeutic target and prognostic marker in oral cancer.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Oral diseases - 30(2024), 2 vom: 25. März, Seite 140-148 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Bowen [VerfasserIn] |
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| Links: |
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| Themen: |
Circ-OMAC |
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| Anmerkungen: |
Date Completed 01.03.2024 Date Revised 01.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/odi.14387 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM346517435 |
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| 245 | 1 | 0 | |a Circ-OMAC drives metastasis in oral squamous cell carcinoma |
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| 500 | |a Date Completed 01.03.2024 | ||
| 500 | |a Date Revised 01.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 Wiley Periodicals LLC. | ||
| 520 | |a OBJECTIVES: Accumulating studies have proved that the circular RNAs (circRNAs) play vital roles in human cancers. However, few circRNAs have been elucidated with lymph node metastasis. This study demonstrated that circ-oral cancer metastasis-associated circRNA (circ-OMAC) is required to regulate the oral squamous cell carcinoma (OSCC) metastasis | ||
| 520 | |a MATERIALS AND METHODS: The circ-OMAC were detected by circRNA-sequencing and further verified by in situ hybridization (ISH). The role of circ-OMAC was assessed by transwell assay and wound healing assay. Mechanistically, circ-OMAC regulated OSCC metastasis by initiating the epithelial-to-mesenchymal transition (EMT) signaling pathway | ||
| 520 | |a RESULTS: Our findings suggested that circ-OMAC was aberrantly elevated in the metastatic lymph nodes as compared to primary OSCC tissues. OSCC patients with high levels of circ-OMAC were prone to a poor prognosis. By developing functional assays, we confirmed that circ-OMAC promotes metastasis of OSCC cells via initiation of EMT pathways | ||
| 520 | |a CONCLUSIONS: We provide new insights whereby Circ-OMAC as an oncogene is a potential therapeutic target and prognostic marker in oral cancer | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a circ-OMAC | |
| 650 | 4 | |a epithelial-to-mesenchymal transition | |
| 650 | 4 | |a lymph node metastasis | |
| 650 | 4 | |a oral squamous cell carcinoma | |
| 650 | 7 | |a RNA, Circular |2 NLM | |
| 650 | 7 | |a MicroRNAs |2 NLM | |
| 700 | 1 | |a Xie, Shule |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Guokai |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Zhaoyu |e verfasserin |4 aut | |
| 700 | 1 | |a Ren, Siqi |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Suling |e verfasserin |4 aut | |
| 700 | 1 | |a Fan, Song |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Jinsong |e verfasserin |4 aut | |
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