Skeletal status in children and adolescents with new-onset type 1 diabetes : a preliminary study based on bone densitometry and quantitative ultrasound
INTRODUCTION: Type 1 diabetes (T1D) represents a risk factor for bone loss and impaired bone quality.
MATERIAL AND METHODS: We conducted an exploratory retrospective cross-sectional study involving youths with new-onset T1D, to investigate the relationship between lumbar spine dual-energy X-ray absorptiometry (DXA) and phalangeal quantitative ultrasound (QUS) measurements, along with their correlation with markers of bone turnover, glucose homeostasis, and residual β-cell function.
RESULTS: 17 children and adolescents (8 females) with recent-onset T1D were enrolled into this study. Lumbar spine areal bone mineral density (aBMD) and age-adjusted amplitude-dependent speed of sound (AD-SoS) Z-scores were indicative of low BMD status (≤ -2.0 SD) in 11.7% and 17.6% of participants, respectively. Spearman's correlation analysis revealed significant inverse correlations between AD-SoS values and circulating levels of β-CrossLaps, alkaline phosphatase, and osteocalcin, along with a significant positive correlation between bone transmission time (BTT) values and fasting plasma C-peptide (FCP) levels. There was no statistically significant correlation between DXA-QUS parameters, fasting plasma glucose (FPG), and glycated haemoglobin (HbA1c). Finally, there was a significant positive correlation between lumbar spine aBMD and BTT values.
CONCLUSIONS: Our study suggests that DXA and/or QUS parameters may be altered in a small proportion of T1D children and adolescents at the disease onset. Additionally, residual β-cell function may represent a protective factor against T1D-related detrimental skeletal changes. Large and long-term prospective studies are needed to confirm these preliminary findings since the present study is limited by the retrospective cross-sectional design and by its small sample size.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
Pediatric endocrinology, diabetes, and metabolism - 28(2022), 3 vom: 05., Seite 197-206 |
| Sprache: |
Englisch |
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| Weiterer Titel: |
Stan szkieletu u dzieci i młodzieży z nowo rozpoznaną cukrzycą typu 1: badanie wstępne oparte na densytometrii kości i ilościowej metodzie ultradźwiękowej |
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| Beteiligte Personen: |
Silvestri, Francesca [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 14.10.2022 Date Revised 06.06.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.5114/pedm.2022.118317 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM346510813 |
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| 245 | 1 | 0 | |a Skeletal status in children and adolescents with new-onset type 1 diabetes |b a preliminary study based on bone densitometry and quantitative ultrasound |
| 246 | 3 | 3 | |a Stan szkieletu u dzieci i młodzieży z nowo rozpoznaną cukrzycą typu 1: badanie wstępne oparte na densytometrii kości i ilościowej metodzie ultradźwiękowej |
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| 500 | |a Date Completed 14.10.2022 | ||
| 500 | |a Date Revised 06.06.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a INTRODUCTION: Type 1 diabetes (T1D) represents a risk factor for bone loss and impaired bone quality | ||
| 520 | |a MATERIAL AND METHODS: We conducted an exploratory retrospective cross-sectional study involving youths with new-onset T1D, to investigate the relationship between lumbar spine dual-energy X-ray absorptiometry (DXA) and phalangeal quantitative ultrasound (QUS) measurements, along with their correlation with markers of bone turnover, glucose homeostasis, and residual β-cell function | ||
| 520 | |a RESULTS: 17 children and adolescents (8 females) with recent-onset T1D were enrolled into this study. Lumbar spine areal bone mineral density (aBMD) and age-adjusted amplitude-dependent speed of sound (AD-SoS) Z-scores were indicative of low BMD status (≤ -2.0 SD) in 11.7% and 17.6% of participants, respectively. Spearman's correlation analysis revealed significant inverse correlations between AD-SoS values and circulating levels of β-CrossLaps, alkaline phosphatase, and osteocalcin, along with a significant positive correlation between bone transmission time (BTT) values and fasting plasma C-peptide (FCP) levels. There was no statistically significant correlation between DXA-QUS parameters, fasting plasma glucose (FPG), and glycated haemoglobin (HbA1c). Finally, there was a significant positive correlation between lumbar spine aBMD and BTT values | ||
| 520 | |a CONCLUSIONS: Our study suggests that DXA and/or QUS parameters may be altered in a small proportion of T1D children and adolescents at the disease onset. Additionally, residual β-cell function may represent a protective factor against T1D-related detrimental skeletal changes. Large and long-term prospective studies are needed to confirm these preliminary findings since the present study is limited by the retrospective cross-sectional design and by its small sample size | ||
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| 700 | 1 | |a Infante, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Fabbri, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrara, Carla |e verfasserin |4 aut | |
| 700 | 1 | |a Ferraguti, Giampiero |e verfasserin |4 aut | |
| 700 | 1 | |a Costantino, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrari, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Bonci, Enea |e verfasserin |4 aut | |
| 700 | 1 | |a Turchetti, Arianna |e verfasserin |4 aut | |
| 700 | 1 | |a Tiberti, Claudio |e verfasserin |4 aut | |
| 700 | 1 | |a Tromba, Valeria |e verfasserin |4 aut | |
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