Antiglycation potential of plant based TiO2 nanoparticle in D-ribose glycated BSA in vitro
© 2022 John Wiley & Sons Ltd..
Biosynthetic procedure is one of the best alternatives, inexpensive and ecologically sound for the synthesis of titanium dioxide (TiO2 ) nanoparticles using a methanolic extract of medicinal plant. The main prospect of this study was to investigate the antiglycation activity of the TiO2 nanoparticles (TNP) prepared by ethanolic leaf extract of the Coleus scutellarioides. In this study, biosynthesized TNP characterized with UV-Visible spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscope. These TNP were further investigated with respect to their antiglycation property and it was checked in the mixture of d-ribose glycated bovine serum albumin (BSA) by measuring ketoamine, carbonyl content, Advanced glycation end products (AGEs) and aggregation of protein instigated by glycation process. The inhibitory effect of TNP to restore the structure of BSA in presence of d-ribose were also characterize by biophysical techniques mentioned above. Therefore, the findings of this study suggest repurposing of TNP for its antiglycation property that could be helpful in prevention of glycation instigated AGEs formation and structural loss of proteins.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
Cell biochemistry and function - 40(2022), 7 vom: 21. Okt., Seite 784-796 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Alenazi, Fahaad [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 03.10.2022 Date Revised 03.10.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/cbf.3744 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Biosynthetic procedure is one of the best alternatives, inexpensive and ecologically sound for the synthesis of titanium dioxide (TiO2 ) nanoparticles using a methanolic extract of medicinal plant. The main prospect of this study was to investigate the antiglycation activity of the TiO2 nanoparticles (TNP) prepared by ethanolic leaf extract of the Coleus scutellarioides. In this study, biosynthesized TNP characterized with UV-Visible spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscope. These TNP were further investigated with respect to their antiglycation property and it was checked in the mixture of d-ribose glycated bovine serum albumin (BSA) by measuring ketoamine, carbonyl content, Advanced glycation end products (AGEs) and aggregation of protein instigated by glycation process. The inhibitory effect of TNP to restore the structure of BSA in presence of d-ribose were also characterize by biophysical techniques mentioned above. Therefore, the findings of this study suggest repurposing of TNP for its antiglycation property that could be helpful in prevention of glycation instigated AGEs formation and structural loss of proteins | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Zafar, Mubashir |e verfasserin |4 aut | |
| 700 | 1 | |a Alharbi, Mohammed Salem |e verfasserin |4 aut | |
| 700 | 1 | |a Al Hagbani, Turki |e verfasserin |4 aut | |
| 700 | 1 | |a Khan, Mohd Yasir |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmad, Waseem |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmad, Saheem |e verfasserin |4 aut | |
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