New Antifibroblastic Medication in Dermatology : Could Nintedanib Treat Scarring?
© 2022 Cristodor et al..
There are a wide variety of disfiguring dermatological conditions whose pathologic substrate is represented by the unwanted deposition of collagen from dermal fibroblasts. Pirfenidone has demonstrated efficiency in the treatment of disordered collagen production when applied topically. Due to a similar mechanism of action, we also hypothesize that a similar medication, nintedanib, might have similar applications. We also propose that a liposomal technology may assist in the penetration of nintedanib and enhance its clinical effects.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
International journal of general medicine - 15(2022) vom: 14., Seite 7169-7172 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cristodor, Patricia Liana [VerfasserIn] |
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| Links: |
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| Themen: |
Fibroblast |
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| Anmerkungen: |
Date Revised 20.09.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.2147/IJGM.S377073 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a There are a wide variety of disfiguring dermatological conditions whose pathologic substrate is represented by the unwanted deposition of collagen from dermal fibroblasts. Pirfenidone has demonstrated efficiency in the treatment of disordered collagen production when applied topically. Due to a similar mechanism of action, we also hypothesize that a similar medication, nintedanib, might have similar applications. We also propose that a liposomal technology may assist in the penetration of nintedanib and enhance its clinical effects | ||
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