Factors associated with the development of second primary tumours in head and neck cancer patients
© 2022 The Authors. European Journal of Cancer Care published by John Wiley & Sons Ltd..
INTRODUCTION: The development of second primary tumours (SPTs) is one of the main causes of low survival in patients with head and neck cancer (HNC). The aim of this study was to review the evidence about factors associated with developing SPTs in patients with HNC.
METHODS: An updated systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, and the search was performed in Pubmed and Scopus. Only original articles with a cohort or case-control design were included. Article quality was assessed with the Newcastle-Ottawa scale.
RESULTS: Thirty-six and two case-control studies were included, with quality medium (n = 5) to high (n = 33). Tobacco showed a significant association with SPT development, with risks ranging from 1.41 (95%CI: 1.04-1.91) to 5.52 (95%CI: 2.91-10.49). Regarding alcohol, risks ranged from 1.46 (95%CI: 1.12-1.91) to 21.3 (95%CI: 2.9-156). Location of the index tumour in the hypopharynx/oropharynx, absence of human papillomavirus and presence of a premalignant lesion also increased the risk of SPTs. More controversy was found for sex, age and other clinical factors of the tumour.
CONCLUSION: Toxic lifestyle habits and clinical factors were associated with the risk of SPTs in HNC patients. These findings may improve individualised prevention strategies in its follow-up.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
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| Enthalten in: |
European journal of cancer care - 31(2022), 6 vom: 19. Nov., Seite e13699 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Salcedo-Bellido, Inmaculada [VerfasserIn] |
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| Links: |
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| Themen: |
Head and neck cancer |
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| Anmerkungen: |
Date Completed 29.11.2022 Date Revised 29.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/ecc.13699 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM346340276 |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 The Authors. European Journal of Cancer Care published by John Wiley & Sons Ltd. | ||
| 520 | |a INTRODUCTION: The development of second primary tumours (SPTs) is one of the main causes of low survival in patients with head and neck cancer (HNC). The aim of this study was to review the evidence about factors associated with developing SPTs in patients with HNC | ||
| 520 | |a METHODS: An updated systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, and the search was performed in Pubmed and Scopus. Only original articles with a cohort or case-control design were included. Article quality was assessed with the Newcastle-Ottawa scale | ||
| 520 | |a RESULTS: Thirty-six and two case-control studies were included, with quality medium (n = 5) to high (n = 33). Tobacco showed a significant association with SPT development, with risks ranging from 1.41 (95%CI: 1.04-1.91) to 5.52 (95%CI: 2.91-10.49). Regarding alcohol, risks ranged from 1.46 (95%CI: 1.12-1.91) to 21.3 (95%CI: 2.9-156). Location of the index tumour in the hypopharynx/oropharynx, absence of human papillomavirus and presence of a premalignant lesion also increased the risk of SPTs. More controversy was found for sex, age and other clinical factors of the tumour | ||
| 520 | |a CONCLUSION: Toxic lifestyle habits and clinical factors were associated with the risk of SPTs in HNC patients. These findings may improve individualised prevention strategies in its follow-up | ||
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a head and neck cancer | |
| 650 | 4 | |a second primary tumours | |
| 700 | 1 | |a Requena, Pilar |e verfasserin |4 aut | |
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| 700 | 1 | |a Lozano-Lorca, Macarena |e verfasserin |4 aut | |
| 700 | 1 | |a Arrebola, Juan Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a Barrios-Rodríguez, Rocío |e verfasserin |4 aut | |
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