Paratesticular Dedifferentiated Liposarcoma with Epithelioid Features : A Diagnostic Pitfall
Well-differentiated/dedifferentiated liposarcoma (WDLPS/DDLPS) represent a significant number of sarcomas arising within the paratesticular region. DDLPS is notorious for a broad histologic spectrum, but epithelioid morphology is rare. Herein, we describe a unique case of paratesticular DDLPS with prominent epithelioid features and molecular confirmation. The patient is 71-year-old-male who presented with multiple paratesticular masses. Morphologic review of the resection specimen revealed a biphasic adipocytic neoplasm consistent with DDLPS. Additionally, epithelioid foci with acinar and nested architecture and focal keratin expression were noted. These areas raised the possibility of a secondary neoplasm including sex cord stromal tumor, germ cell tumor, and paraganglioma. However, MDM2 immunohistochemistry and FISH showed these areas to express MDM2 and exhibit MDM2 amplification, respectively, confirming that they represented a component of DDLPS. This case further highlights the morphologic diversity of DDLPS as well as the utility of MDM2 studies.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
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Enthalten in: |
International journal of surgical pathology - 31(2023), 5 vom: 28. Aug., Seite 721-727 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Patton, Ashley [VerfasserIn] |
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Links: |
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Themen: |
Case Reports |
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Anmerkungen: |
Date Completed 03.07.2023 Date Revised 03.07.2023 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1177/10668969221120780 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM346301939 |
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520 | |a Well-differentiated/dedifferentiated liposarcoma (WDLPS/DDLPS) represent a significant number of sarcomas arising within the paratesticular region. DDLPS is notorious for a broad histologic spectrum, but epithelioid morphology is rare. Herein, we describe a unique case of paratesticular DDLPS with prominent epithelioid features and molecular confirmation. The patient is 71-year-old-male who presented with multiple paratesticular masses. Morphologic review of the resection specimen revealed a biphasic adipocytic neoplasm consistent with DDLPS. Additionally, epithelioid foci with acinar and nested architecture and focal keratin expression were noted. These areas raised the possibility of a secondary neoplasm including sex cord stromal tumor, germ cell tumor, and paraganglioma. However, MDM2 immunohistochemistry and FISH showed these areas to express MDM2 and exhibit MDM2 amplification, respectively, confirming that they represented a component of DDLPS. This case further highlights the morphologic diversity of DDLPS as well as the utility of MDM2 studies | ||
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700 | 1 | |a Alruwaii, Fatimah I |e verfasserin |4 aut | |
700 | 1 | |a Angulo, Karen Arispe |e verfasserin |4 aut | |
700 | 1 | |a Fuller, Lanisha D |e verfasserin |4 aut | |
700 | 1 | |a Calvaresi, Emilia |e verfasserin |4 aut | |
700 | 1 | |a Billings, Steven D |e verfasserin |4 aut | |
700 | 1 | |a Goldblum, John R |e verfasserin |4 aut | |
700 | 1 | |a Fritchie, Karen J |e verfasserin |4 aut | |
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