Mussel-Inspired Hydrogels for Fluoride Delivery and Caries Prevention
Fluoride agents hold promise for the repair and prevention of caries lesions, but their interaction with enamel is often hampered and diminished because of the dynamic wet environment in the oral cavity, which affects the efficacy of fluoride delivery and limits treatment success. We herein developed a mussel-inspired wet adhesive fluoride system (denoted TSNaF) fabricated by the self-assembly of tannic acid (TA), silk fibroin (SF), and sodium fluoride (NaF). TS@NaF demonstrated remarkable biological stability and biocompatibility, showed reliable wet adhesion, released fluoride ions (F-) topically, and induced significant deposition of calcium fluoride (CaF2) onto enamel in vitro. Furthermore, TS@NaF provided an anticaries effect in vitro and induced a detectable increase in enamel mineral density. Advanced fluoride-releasing bioadhesives are therefore promising candidates for caries prevention and highlight the great potential of mussel-inspired dental materials in clinical applications.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:101 |
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| Enthalten in: |
Journal of dental research - 101(2022), 13 vom: 14. Dez., Seite 1597-1605 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhen, L [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 22.11.2022 Date Revised 28.11.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1177/00220345221114783 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM346298377 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Fluoride agents hold promise for the repair and prevention of caries lesions, but their interaction with enamel is often hampered and diminished because of the dynamic wet environment in the oral cavity, which affects the efficacy of fluoride delivery and limits treatment success. We herein developed a mussel-inspired wet adhesive fluoride system (denoted TSNaF) fabricated by the self-assembly of tannic acid (TA), silk fibroin (SF), and sodium fluoride (NaF). TS@NaF demonstrated remarkable biological stability and biocompatibility, showed reliable wet adhesion, released fluoride ions (F-) topically, and induced significant deposition of calcium fluoride (CaF2) onto enamel in vitro. Furthermore, TS@NaF provided an anticaries effect in vitro and induced a detectable increase in enamel mineral density. Advanced fluoride-releasing bioadhesives are therefore promising candidates for caries prevention and highlight the great potential of mussel-inspired dental materials in clinical applications | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Liang, K |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, J |e verfasserin |4 aut | |
| 700 | 1 | |a Ke, X |e verfasserin |4 aut | |
| 700 | 1 | |a Tao, S |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, M |e verfasserin |4 aut | |
| 700 | 1 | |a Yuan, H |e verfasserin |4 aut | |
| 700 | 1 | |a He, L |e verfasserin |4 aut | |
| 700 | 1 | |a Bidlack, F B |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, J |e verfasserin |4 aut | |
| 700 | 1 | |a Li, J |e verfasserin |4 aut | |
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