In silico Study of Acetylcholinesterase and Beta-secretase Inhibitors : Potential Multitarget Anti-Alzheimer's Agents
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Alzheimer's disease is a progressive neurodegenerative process with multifactorial characteristics. This disease follows the natural aging process, affecting mainly people over 65 years. Pharmacotherapeutic treatment currently combats symptoms related to cognitive function. Several targets have begun to attract the interest of the scientific community to develop new drug candidates which have better pharmacokinetic and lower toxicity parameters.
OBJECTIVE: The present study aims to design new candidates for acetylcholinesterase/β-secretase (AChE/BACE1) multitarget inhibitor drugs.
METHODS: 17 natural products were selected from the literature with anticholinesterase activity and 1 synthetic molecule with inhibitory activity for BACE1. Subsequently, the molecular docking study was performed, followed by the derivation of the pharmacophoric pattern and prediction of pharmacokinetic and toxicological properties. Finally, the hybrid prototype was designed.
RESULTS: All selected molecules showed interactions with their respective target enzymes. Derivation of the pharmacophoric pattern from molecules that interacted with the AChE enzyme resulted in 3 pharmacophoric regions: an aromatic ring, an electron-acceptor region and a hydrophobic region. The molecules showed good pharmacokinetic and toxicological results, showing no warnings of mutagenicity and/or carcinogenicity. After the hybridization process, three hybrid molecules were obtained, which showed inhibitory activity for both targets.
CONCLUSION: It is concluded that research in the field of medicinal chemistry is advancing towards the discovery of new drug candidates that bring a better quality of life to patients with AD.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Central nervous system agents in medicinal chemistry - 22(2022), 2 vom: 21., Seite 139-150 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
da Costa, Daniel Castro [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 16.09.2022 Date Revised 16.09.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.2174/1871524922666220517110606 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM346216575 |
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| 100 | 1 | |a da Costa, Daniel Castro |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a In silico Study of Acetylcholinesterase and Beta-secretase Inhibitors |b Potential Multitarget Anti-Alzheimer's Agents |
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| 500 | |a Date Completed 16.09.2022 | ||
| 500 | |a Date Revised 16.09.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Alzheimer's disease is a progressive neurodegenerative process with multifactorial characteristics. This disease follows the natural aging process, affecting mainly people over 65 years. Pharmacotherapeutic treatment currently combats symptoms related to cognitive function. Several targets have begun to attract the interest of the scientific community to develop new drug candidates which have better pharmacokinetic and lower toxicity parameters | ||
| 520 | |a OBJECTIVE: The present study aims to design new candidates for acetylcholinesterase/β-secretase (AChE/BACE1) multitarget inhibitor drugs | ||
| 520 | |a METHODS: 17 natural products were selected from the literature with anticholinesterase activity and 1 synthetic molecule with inhibitory activity for BACE1. Subsequently, the molecular docking study was performed, followed by the derivation of the pharmacophoric pattern and prediction of pharmacokinetic and toxicological properties. Finally, the hybrid prototype was designed | ||
| 520 | |a RESULTS: All selected molecules showed interactions with their respective target enzymes. Derivation of the pharmacophoric pattern from molecules that interacted with the AChE enzyme resulted in 3 pharmacophoric regions: an aromatic ring, an electron-acceptor region and a hydrophobic region. The molecules showed good pharmacokinetic and toxicological results, showing no warnings of mutagenicity and/or carcinogenicity. After the hybridization process, three hybrid molecules were obtained, which showed inhibitory activity for both targets | ||
| 520 | |a CONCLUSION: It is concluded that research in the field of medicinal chemistry is advancing towards the discovery of new drug candidates that bring a better quality of life to patients with AD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Alzheimer's disease | |
| 650 | 4 | |a anticholinesterases | |
| 650 | 4 | |a molecular docking | |
| 650 | 4 | |a molecular modeling | |
| 650 | 4 | |a multitarget drugs | |
| 650 | 4 | |a β-secretase | |
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| 650 | 7 | |a Amyloid Precursor Protein Secretases |2 NLM | |
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| 650 | 7 | |a Aspartic Acid Endopeptidases |2 NLM | |
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| 700 | 1 | |a Teixeira, Hueldem Ronam Cristo |e verfasserin |4 aut | |
| 700 | 1 | |a Silva, Raí Campos |e verfasserin |4 aut | |
| 700 | 1 | |a Francischini, Isaque Antonio Galindo |e verfasserin |4 aut | |
| 700 | 1 | |a de Paula da Silva, Carlos Henrique Tomich |e verfasserin |4 aut | |
| 700 | 1 | |a da Silva Hage-Melim, Lorane Izabel |e verfasserin |4 aut | |
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