Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1
Copyright © 2022 Elsevier Inc. All rights reserved..
The tumor microenvironment (TME) is a unique niche governed by constant crosstalk within and across all intratumoral cellular compartments. In particular, intratumoral high potassium (K+) has shown immune-suppressive potency on T cells. However, as a pan-cancer characteristic associated with local necrosis, the impact of this ionic disturbance on innate immunity is unknown. Here, we reveal that intratumoral high K+ suppresses the anti-tumor capacity of tumor-associated macrophages (TAMs). We identify the inwardly rectifying K+ channel Kir2.1 as a central modulator of TAM functional polarization in high K+ TME, and its conditional depletion repolarizes TAMs toward an anti-tumor state, sequentially boosting local anti-tumor immunity. Kir2.1 deficiency disturbs the electrochemically dependent glutamine uptake, engendering TAM metabolic reprogramming from oxidative phosphorylation toward glycolysis. Kir2.1 blockade attenuates both murine tumor- and patient-derived xenograft growth. Collectively, our findings reveal Kir2.1 as a determinant and potential therapeutic target for regaining the anti-tumor capacity of TAMs within ionic-imbalanced TME.
| Errataetall: |
CommentIn: Cell Metab. 2022 Nov 1;34(11):1613-1615. - PMID 36323230 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
|---|---|
| Enthalten in: |
Cell metabolism - 34(2022), 11 vom: 01. Nov., Seite 1843-1859.e11 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Chen, Sheng [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Immunometabolism |
|---|
| Anmerkungen: |
Date Completed 04.11.2022 Date Revised 09.01.2023 published: Print-Electronic CommentIn: Cell Metab. 2022 Nov 1;34(11):1613-1615. - PMID 36323230 Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.cmet.2022.08.016 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM346206995 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM346206995 | ||
| 003 | DE-627 | ||
| 005 | 20231226030850.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.cmet.2022.08.016 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1153.xml |
| 035 | |a (DE-627)NLM346206995 | ||
| 035 | |a (NLM)36103895 | ||
| 035 | |a (PII)S1550-4131(22)00359-X | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Chen, Sheng |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1 |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 04.11.2022 | ||
| 500 | |a Date Revised 09.01.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Cell Metab. 2022 Nov 1;34(11):1613-1615. - PMID 36323230 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier Inc. All rights reserved. | ||
| 520 | |a The tumor microenvironment (TME) is a unique niche governed by constant crosstalk within and across all intratumoral cellular compartments. In particular, intratumoral high potassium (K+) has shown immune-suppressive potency on T cells. However, as a pan-cancer characteristic associated with local necrosis, the impact of this ionic disturbance on innate immunity is unknown. Here, we reveal that intratumoral high K+ suppresses the anti-tumor capacity of tumor-associated macrophages (TAMs). We identify the inwardly rectifying K+ channel Kir2.1 as a central modulator of TAM functional polarization in high K+ TME, and its conditional depletion repolarizes TAMs toward an anti-tumor state, sequentially boosting local anti-tumor immunity. Kir2.1 deficiency disturbs the electrochemically dependent glutamine uptake, engendering TAM metabolic reprogramming from oxidative phosphorylation toward glycolysis. Kir2.1 blockade attenuates both murine tumor- and patient-derived xenograft growth. Collectively, our findings reveal Kir2.1 as a determinant and potential therapeutic target for regaining the anti-tumor capacity of TAMs within ionic-imbalanced TME | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Kir2.1 | |
| 650 | 4 | |a immunometabolism | |
| 650 | 4 | |a potassium | |
| 650 | 4 | |a tumor microenvironment | |
| 650 | 4 | |a tumor-associated macrophage | |
| 650 | 7 | |a Potassium Channels, Inwardly Rectifying |2 NLM | |
| 650 | 7 | |a Potassium |2 NLM | |
| 650 | 7 | |a RWP5GA015D |2 NLM | |
| 700 | 1 | |a Cui, Wenyu |e verfasserin |4 aut | |
| 700 | 1 | |a Chi, Zhexu |e verfasserin |4 aut | |
| 700 | 1 | |a Xiao, Qian |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Tianyi |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Qizhen |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Kaixiang |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Weiwei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Zhen |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Chengxuan |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Xiang |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Siqi |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Qi |e verfasserin |4 aut | |
| 700 | 1 | |a Jin, Jiacheng |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Mobai |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Dehang |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Qianzhou |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Quanquan |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Xiafei |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xue |e verfasserin |4 aut | |
| 700 | 1 | |a Qian, Junbin |e verfasserin |4 aut | |
| 700 | 1 | |a Ding, Kefeng |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Di |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cell metabolism |d 2005 |g 34(2022), 11 vom: 01. Nov., Seite 1843-1859.e11 |w (DE-627)NLM156885433 |x 1932-7420 |7 nnns |
| 773 | 1 | 8 | |g volume:34 |g year:2022 |g number:11 |g day:01 |g month:11 |g pages:1843-1859.e11 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.cmet.2022.08.016 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 34 |j 2022 |e 11 |b 01 |c 11 |h 1843-1859.e11 | ||