Ferritin as a predictive biomarker of severity in Covid-19
Background: To prevent the crisis-level shortage of beds in hospitals and for a more efficient support, it’s necessary to early identify coronavirus disease-19 (Covid-19) patients at risk to develop a severe form of the disease.
Objective: The goal of our study was to determine whether biological markers, including the serum ferritin, could predict the severity of the Covid-19.
Methods: One hundred and seventy-one patients, who were admitted to Caen University Hospital, were included retrospectively with a positive diagnosis of Covid-19 by RT-PCR. A serum ferritin measurement was performed for all patients. They were further classified either into a non-severe or a severe group based on their hospitalization in intense care unit (ICU) for mechanical ventilation or death.
Results: Univariate analysis revealed a significant association between increased serum ferritin and CRP levels, obesity, CT scan lesions, pathological respiratory rate, decreased PaO2/FiO2 ratio, the NEWS-2 score and the severe (n = 59) vs the non-severe (n = 112) outcome of Covid-19 patients. However, in a multivariate analysis, only CRP and obesity were associated with the severe form of Covid-19.
Conclusion: While pathological level of serum ferritin at admission is associated with severe form of Covid-19, combination of increased CRP level and obesity would better predict the severity of the disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:80 |
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| Enthalten in: |
Annales de biologie clinique - 80(2022), 4 vom: 01. Juli, Seite 363-368 |
| Sprache: |
Englisch |
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| Weiterer Titel: |
La ferritine comme biomarqueur prédictif des formes sévères de Covid-19 |
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| Beteiligte Personen: |
Perottet, Jérémy [VerfasserIn] |
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| Links: |
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| Themen: |
9007-73-2 |
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| Anmerkungen: |
Date Completed 15.09.2022 Date Revised 15.09.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1684/abc.2022.1725 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM346162343 |
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| 246 | 3 | 3 | |a La ferritine comme biomarqueur prédictif des formes sévères de Covid-19 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Background: To prevent the crisis-level shortage of beds in hospitals and for a more efficient support, it’s necessary to early identify coronavirus disease-19 (Covid-19) patients at risk to develop a severe form of the disease | ||
| 520 | |a Objective: The goal of our study was to determine whether biological markers, including the serum ferritin, could predict the severity of the Covid-19 | ||
| 520 | |a Methods: One hundred and seventy-one patients, who were admitted to Caen University Hospital, were included retrospectively with a positive diagnosis of Covid-19 by RT-PCR. A serum ferritin measurement was performed for all patients. They were further classified either into a non-severe or a severe group based on their hospitalization in intense care unit (ICU) for mechanical ventilation or death | ||
| 520 | |a Results: Univariate analysis revealed a significant association between increased serum ferritin and CRP levels, obesity, CT scan lesions, pathological respiratory rate, decreased PaO2/FiO2 ratio, the NEWS-2 score and the severe (n = 59) vs the non-severe (n = 112) outcome of Covid-19 patients. However, in a multivariate analysis, only CRP and obesity were associated with the severe form of Covid-19 | ||
| 520 | |a Conclusion: While pathological level of serum ferritin at admission is associated with severe form of Covid-19, combination of increased CRP level and obesity would better predict the severity of the disease | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ferritin | |
| 650 | 4 | |a CRP | |
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| 650 | 4 | |a Covid-19 | |
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| 700 | 1 | |a Creveuil, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Allouche, Stéphane |e verfasserin |4 aut | |
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