Advances in the synthesis of three typical tetraterpenoids including β-carotene, lycopene and astaxanthin
Copyright © 2022 Elsevier Inc. All rights reserved..
Carotenoids are natural pigments that widely exist in nature. Due to their excellent antioxidant, anticancer and anti-inflammatory properties, carotenoids are commonly used in food, medicine, cosmetic and other fields. At present, natural carotenoids are mainly extracted from plants, algae and microorganisms. With the rapid development of metabolic engineering and molecular biology as well as the continuous in-depth study of carotenoids synthesis pathways, industrial microorganisms have showed promising applications in the synthesis of carotenoids. In this review, we introduced the properties of several carotenoids and their biosynthetic metabolism process. Then, the microorganisms synthesizing carotenoids through the natural and non-natural pathways and the extraction methods of carotenoids were summarized and compared. Meanwhile, the influence of substrates on the carotenoids production was also listed. The methods and strategies for achieving high carotenoid production are categorized to help with future research.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:61 |
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| Enthalten in: |
Biotechnology advances - 61(2022) vom: 01. Dez., Seite 108033 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jing, Yiwen [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 22.11.2022 Date Revised 04.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.biotechadv.2022.108033 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2022 Elsevier Inc. All rights reserved. | ||
| 520 | |a Carotenoids are natural pigments that widely exist in nature. Due to their excellent antioxidant, anticancer and anti-inflammatory properties, carotenoids are commonly used in food, medicine, cosmetic and other fields. At present, natural carotenoids are mainly extracted from plants, algae and microorganisms. With the rapid development of metabolic engineering and molecular biology as well as the continuous in-depth study of carotenoids synthesis pathways, industrial microorganisms have showed promising applications in the synthesis of carotenoids. In this review, we introduced the properties of several carotenoids and their biosynthetic metabolism process. Then, the microorganisms synthesizing carotenoids through the natural and non-natural pathways and the extraction methods of carotenoids were summarized and compared. Meanwhile, the influence of substrates on the carotenoids production was also listed. The methods and strategies for achieving high carotenoid production are categorized to help with future research | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Carotenoids | |
| 650 | 4 | |a Metabolic engineering | |
| 650 | 4 | |a Microorganism | |
| 650 | 4 | |a Synthetic biology | |
| 650 | 7 | |a beta Carotene |2 NLM | |
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| 650 | 7 | |a astaxanthine |2 NLM | |
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| 700 | 1 | |a Wang, Yanxia |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Dawei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jingnan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Jiawen |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Jingxiang |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Yifan |e verfasserin |4 aut | |
| 700 | 1 | |a Xin, Fengxue |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Wenming |e verfasserin |4 aut | |
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