Simulating Stenotic Conditions of the Coronary Artery in a Lumped Parameter Model of the Cardiovascular System
Coronary flow control mechanisms maintain the average coronary blood flow (CBF) at 4% of the cardiac output (CO) in normal adults, with no prior diagnosis of coronary artery disease (CAD), under resting conditions. This paper explores a pulsatile sixth order lumped parameter (LP) model of the cardiovascular system (CVS) which utilizes the average CBF approximated from CO along with arterial blood pressure (ABP) waveform to estimate the coronary microvascular resistance using non-linear least square optimization technique. The CVS model includes a third order model of the coronary vascular bed and is shown to achieve phasic coronary flow. The coronary epicardial resistance is varied to emulate different degrees of stenosis and achieve realistic behavior of coronary microvascular resistance under these conditions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2022 |
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| Enthalten in: |
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference - 2022(2022) vom: 09. Juli, Seite 3993-3996 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sahoo, Karuna P [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 13.09.2022 Date Revised 20.10.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1109/EMBC48229.2022.9871066 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM346032229 |
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| 520 | |a Coronary flow control mechanisms maintain the average coronary blood flow (CBF) at 4% of the cardiac output (CO) in normal adults, with no prior diagnosis of coronary artery disease (CAD), under resting conditions. This paper explores a pulsatile sixth order lumped parameter (LP) model of the cardiovascular system (CVS) which utilizes the average CBF approximated from CO along with arterial blood pressure (ABP) waveform to estimate the coronary microvascular resistance using non-linear least square optimization technique. The CVS model includes a third order model of the coronary vascular bed and is shown to achieve phasic coronary flow. The coronary epicardial resistance is varied to emulate different degrees of stenosis and achieve realistic behavior of coronary microvascular resistance under these conditions | ||
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| 700 | 1 | |a Sinha, Aniruddha |e verfasserin |4 aut | |
| 700 | 1 | |a Khandelwal, Sundeep |e verfasserin |4 aut | |
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