Prevalent vertebral fractures among urban-dwelling Chinese postmenopausal women : a population-based, randomized-sampling, cross-sectional study
© 2022. The Author(s)..
In this population-based, cross-sectional study, we investigated vertebral fracture (VF) prevalence among Chinese postmenopausal women. We found 14.7% of population had VFs, which increased with age. Age ≥ 65 years, hip fracture, and densitometric osteoporosis were significantly associated with VFs. The prevalence of osteoporosis was remarkably high.
PURPOSE: To investigate VF prevalence among Chinese postmenopausal women in this population-based, randomized-sampling, cross-sectional study.
METHODS: The investigator obtained lists of women from communities. Randomization was performed using SAS programming based on age group in each region. Postmenopausal women aged ≥ 50 years in the urban community were included. The investigator interviewed subjects to collect self-reported data and measured BMD. Spine radiographs were adjudicated by Genant's semi-quantitative method. VFs were defined as fractures of at least one vertebra classified by Genant's score 1-3 and were analyzed using descriptive statistics.
RESULTS: A total of 31,205 women listed for randomized sampling from 10 Tier-3 hospitals at 5 regions. Of 2634 women in the full analysis set, 14.7% (388/2634, 95% CI: 13.4, 17.1) had prevalent VFs. VF prevalence increased with age (Cochran-Armitage test p < 0.0001) and was significantly higher in women aged ≥ 65. VF prevalence did not differ between North (14.4%, 95% CI: 12.5, 16.4) and South China (15.1%, 95% CI: 13.3, 17.1). In women with no prior VFs, prevalent VFs were 12.4% (95% CI: 11.2, 13.7). Age ≥ 65 years (OR: 2.57, 95% CI: 1.91, 3.48), hip fracture (OR: 2.28, 95% CI: 1.09, 4.76), and densitometric osteoporosis (OR: 2.52, 95% CI: 1.96, 3.22) were significantly associated with prevalent VFs. Prevalence of osteoporosis was 32.9% measured by BMD and 40.8% using NOF/IOF clinical diagnosis criteria.
CONCLUSION: VFs are prevalent among Chinese postmenopausal women who were ≥ 50 years and community-dwelled. Osteoporosis prevalence is remarkable when fragile fractures were part of clinical diagnosis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Archives of osteoporosis - 17(2022), 1 vom: 07. Sept., Seite 120 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Xia, Weibo [VerfasserIn] |
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| Links: |
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| Themen: |
Community-dwelling |
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| Anmerkungen: |
Date Completed 09.09.2022 Date Revised 17.03.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s11657-022-01158-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM345872886 |
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| 245 | 1 | 0 | |a Prevalent vertebral fractures among urban-dwelling Chinese postmenopausal women |b a population-based, randomized-sampling, cross-sectional study |
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| 500 | |a Date Completed 09.09.2022 | ||
| 500 | |a Date Revised 17.03.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. The Author(s). | ||
| 520 | |a In this population-based, cross-sectional study, we investigated vertebral fracture (VF) prevalence among Chinese postmenopausal women. We found 14.7% of population had VFs, which increased with age. Age ≥ 65 years, hip fracture, and densitometric osteoporosis were significantly associated with VFs. The prevalence of osteoporosis was remarkably high | ||
| 520 | |a PURPOSE: To investigate VF prevalence among Chinese postmenopausal women in this population-based, randomized-sampling, cross-sectional study | ||
| 520 | |a METHODS: The investigator obtained lists of women from communities. Randomization was performed using SAS programming based on age group in each region. Postmenopausal women aged ≥ 50 years in the urban community were included. The investigator interviewed subjects to collect self-reported data and measured BMD. Spine radiographs were adjudicated by Genant's semi-quantitative method. VFs were defined as fractures of at least one vertebra classified by Genant's score 1-3 and were analyzed using descriptive statistics | ||
| 520 | |a RESULTS: A total of 31,205 women listed for randomized sampling from 10 Tier-3 hospitals at 5 regions. Of 2634 women in the full analysis set, 14.7% (388/2634, 95% CI: 13.4, 17.1) had prevalent VFs. VF prevalence increased with age (Cochran-Armitage test p < 0.0001) and was significantly higher in women aged ≥ 65. VF prevalence did not differ between North (14.4%, 95% CI: 12.5, 16.4) and South China (15.1%, 95% CI: 13.3, 17.1). In women with no prior VFs, prevalent VFs were 12.4% (95% CI: 11.2, 13.7). Age ≥ 65 years (OR: 2.57, 95% CI: 1.91, 3.48), hip fracture (OR: 2.28, 95% CI: 1.09, 4.76), and densitometric osteoporosis (OR: 2.52, 95% CI: 1.96, 3.22) were significantly associated with prevalent VFs. Prevalence of osteoporosis was 32.9% measured by BMD and 40.8% using NOF/IOF clinical diagnosis criteria | ||
| 520 | |a CONCLUSION: VFs are prevalent among Chinese postmenopausal women who were ≥ 50 years and community-dwelled. Osteoporosis prevalence is remarkable when fragile fractures were part of clinical diagnosis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Community-dwelling | |
| 650 | 4 | |a Osteoporosis | |
| 650 | 4 | |a Postmenopausal women | |
| 650 | 4 | |a Prevalent vertebral fractures | |
| 650 | 4 | |a Randomized sampling | |
| 700 | 1 | |a Liu, Qiang |e verfasserin |4 aut | |
| 700 | 1 | |a Lv, Jinhan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Zhenlin |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Wen |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Zhongjian |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Jianting |e verfasserin |4 aut | |
| 700 | 1 | |a He, Liang |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Zhenming |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Qiang |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Fang |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jue |e verfasserin |4 aut | |
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