Albiglutide in patients with type 2 diabetes and heart failure : a post-hoc analysis from Harmony Outcomes
© 2022 European Society of Cardiology..
AIM: Glucagon-like peptide-1 receptor agonists (GLP1-RA) improve cardiovascular outcomes in patients with type 2 diabetes (T2D). However, some studies suggest that their effects in patients with heart failure (HF) may be attenuated. We aimed to explore the effects of the GLP1-RA albiglutide on HF outcomes in patients with and without HF history enrolled in the Harmony Outcomes trial.
METHODS AND RESULTS: Harmony Outcomes enrolled patients with T2D and cardiovascular disease randomized to either albiglutide or placebo over a median follow-up of 1.6 years. A total of 9462 patients were included, of whom 1922 (20%) had HF history. Patients with HF had more cardiovascular comorbidities, poorer renal function, and had a three to four-fold higher risk of HF events compared to patients without HF. Compared to placebo, the effect of albiglutide on the composite of cardiovascular death or HF hospitalization was more pronounced among patients without HF (hazard ratio [HR] 0.73, 95% confidence interval [CI] 0.56-0.95) than in patients with HF (HR 1.06, 95% CI 0.79-1.43) (interaction p = 0.062). A similar pattern was observed for HF hospitalizations (interaction p = 0.025). The effect of albiglutide on cardiovascular death, sudden death or 'pump failure' death, and all-cause mortality was also attenuated among patients with HF history, but without significant interaction (p > 0.1). The benefit of albiglutide to reduce atherosclerotic events was consistent regardless of HF history.
CONCLUSIONS: In patients with T2D and cardiovascular disease, albiglutide appeared to have no effect in reducing HF-related events among patients with HF history. These findings, placed in the context of other trials, suggest that GLP1-RA may not improve HF outcomes in patients with HF.
| Errataetall: |
CommentIn: Eur J Heart Fail. 2022 Oct;24(10):1802-1804. - PMID 36189959 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
European journal of heart failure - 24(2022), 10 vom: 19. Okt., Seite 1792-1801 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ferreira, João Pedro [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 28.11.2022 Date Revised 20.12.2022 published: Print-Electronic CommentIn: Eur J Heart Fail. 2022 Oct;24(10):1802-1804. - PMID 36189959 Citation Status MEDLINE |
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| doi: |
10.1002/ejhf.2660 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM345710479 |
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| 100 | 1 | |a Ferreira, João Pedro |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Albiglutide in patients with type 2 diabetes and heart failure |b a post-hoc analysis from Harmony Outcomes |
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| 500 | |a Date Revised 20.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Eur J Heart Fail. 2022 Oct;24(10):1802-1804. - PMID 36189959 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 European Society of Cardiology. | ||
| 520 | |a AIM: Glucagon-like peptide-1 receptor agonists (GLP1-RA) improve cardiovascular outcomes in patients with type 2 diabetes (T2D). However, some studies suggest that their effects in patients with heart failure (HF) may be attenuated. We aimed to explore the effects of the GLP1-RA albiglutide on HF outcomes in patients with and without HF history enrolled in the Harmony Outcomes trial | ||
| 520 | |a METHODS AND RESULTS: Harmony Outcomes enrolled patients with T2D and cardiovascular disease randomized to either albiglutide or placebo over a median follow-up of 1.6 years. A total of 9462 patients were included, of whom 1922 (20%) had HF history. Patients with HF had more cardiovascular comorbidities, poorer renal function, and had a three to four-fold higher risk of HF events compared to patients without HF. Compared to placebo, the effect of albiglutide on the composite of cardiovascular death or HF hospitalization was more pronounced among patients without HF (hazard ratio [HR] 0.73, 95% confidence interval [CI] 0.56-0.95) than in patients with HF (HR 1.06, 95% CI 0.79-1.43) (interaction p = 0.062). A similar pattern was observed for HF hospitalizations (interaction p = 0.025). The effect of albiglutide on cardiovascular death, sudden death or 'pump failure' death, and all-cause mortality was also attenuated among patients with HF history, but without significant interaction (p > 0.1). The benefit of albiglutide to reduce atherosclerotic events was consistent regardless of HF history | ||
| 520 | |a CONCLUSIONS: In patients with T2D and cardiovascular disease, albiglutide appeared to have no effect in reducing HF-related events among patients with HF history. These findings, placed in the context of other trials, suggest that GLP1-RA may not improve HF outcomes in patients with HF | ||
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Albiglutide | |
| 650 | 4 | |a Glucagon-like peptide-1 receptor agonists | |
| 650 | 4 | |a Heart failure | |
| 650 | 4 | |a Type 2 diabetes | |
| 650 | 7 | |a rGLP-1 protein |2 NLM | |
| 650 | 7 | |a 5E7U48495E |2 NLM | |
| 650 | 7 | |a Hypoglycemic Agents |2 NLM | |
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| 700 | 1 | |a Vasques-Nóvoa, Francisco |e verfasserin |4 aut | |
| 700 | 1 | |a Angélico-Gonçalves, António |e verfasserin |4 aut | |
| 700 | 1 | |a Leite, Ana Rita |e verfasserin |4 aut | |
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| 700 | 1 | |a Leite-Moreira, Adelino |e verfasserin |4 aut | |
| 700 | 1 | |a Neves, João Sérgio |e verfasserin |4 aut | |
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