Blood-circulating EV-miRNAs, serum TARC, and quantitative FDG-PET features in classical Hodgkin lymphoma
© 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd..
Blood-based biomarkers are gaining interest for response evaluation in classical Hodgkin lymphoma (cHL). However, it is unknown how blood-based biomarkers relate to quantitative 18F-FDG-PET features. We correlated extracellular vesicle-associated miRNAs (EV-miRNA), serum TARC, and complete blood count (CBC) with PET features (e.g., metabolic tumor volume [MTV], dissemination and intensity features) in 30 cHL patients at baseline. EV-miR127-3p, EV-miR24-3p, sTARC, and several CBC parameters showed weak to strong correlations with MTV and dissemination features, but not with intensity features. Two other EV-miRNAs only showed weak correlations with PET features. Therefore, blood-based biomarkers may be complementary to PET features, which warrants further exploration of combining these biomarkers in prognostic models.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:3 |
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| Enthalten in: |
EJHaem - 3(2022), 3 vom: 01. Aug., Seite 908-912 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Drees, Esther E E [VerfasserIn] |
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| Links: |
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| Themen: |
Extracellular vesicles |
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| Anmerkungen: |
Date Revised 07.09.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1002/jha2.432 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM345683374 |
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| 245 | 1 | 0 | |a Blood-circulating EV-miRNAs, serum TARC, and quantitative FDG-PET features in classical Hodgkin lymphoma |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. | ||
| 520 | |a Blood-based biomarkers are gaining interest for response evaluation in classical Hodgkin lymphoma (cHL). However, it is unknown how blood-based biomarkers relate to quantitative 18F-FDG-PET features. We correlated extracellular vesicle-associated miRNAs (EV-miRNA), serum TARC, and complete blood count (CBC) with PET features (e.g., metabolic tumor volume [MTV], dissemination and intensity features) in 30 cHL patients at baseline. EV-miR127-3p, EV-miR24-3p, sTARC, and several CBC parameters showed weak to strong correlations with MTV and dissemination features, but not with intensity features. Two other EV-miRNAs only showed weak correlations with PET features. Therefore, blood-based biomarkers may be complementary to PET features, which warrants further exploration of combining these biomarkers in prognostic models | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a FDG‐PET | |
| 650 | 4 | |a Hodgkin lymphoma | |
| 650 | 4 | |a Radiomics | |
| 650 | 4 | |a TARC | |
| 650 | 4 | |a extracellular vesicles | |
| 650 | 4 | |a miRNAs | |
| 700 | 1 | |a Driessen, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Zwezerijnen, Gerben J C |e verfasserin |4 aut | |
| 700 | 1 | |a Verkuijlen, Sandra A W M |e verfasserin |4 aut | |
| 700 | 1 | |a Eertink, Jakoba J |e verfasserin |4 aut | |
| 700 | 1 | |a van Eijndhoven, Monique A J |e verfasserin |4 aut | |
| 700 | 1 | |a Groenewegen, Nils J |e verfasserin |4 aut | |
| 700 | 1 | |a Vallés-Martí, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a de Jong, Daphne |e verfasserin |4 aut | |
| 700 | 1 | |a Boellaard, Ronald |e verfasserin |4 aut | |
| 700 | 1 | |a de Vet, Henrica C W |e verfasserin |4 aut | |
| 700 | 1 | |a Pegtel, Dirk M |e verfasserin |4 aut | |
| 700 | 1 | |a Zijlstra, Josée M |e verfasserin |4 aut | |
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