A pH-activated fluorescent probe via transformation of azo and hydrazone forms for lysosomal pH imaging
We developed a fluorescent probe Sth-NH by introducing a 6-hydroxypyridone skeleton. The presence of an active proton enables the probe to transform from a deprotonated azo form to a hydrazone form in a strongly acidic environment to realize fluorescence light-up behavior, thus monitoring the lower lysosomal pH of cancer cells and distinguishing them from normal cells.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:58 |
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| Enthalten in: |
Chemical communications (Cambridge, England) - 58(2022), 76 vom: 22. Sept., Seite 10635-10638 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhao, Xiao-Lei [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 26.09.2022 Date Revised 26.09.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1039/d2cc03999k |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM345647637 |
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| 100 | 1 | |a Zhao, Xiao-Lei |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A pH-activated fluorescent probe via transformation of azo and hydrazone forms for lysosomal pH imaging |
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| 500 | |a Date Completed 26.09.2022 | ||
| 500 | |a Date Revised 26.09.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a We developed a fluorescent probe Sth-NH by introducing a 6-hydroxypyridone skeleton. The presence of an active proton enables the probe to transform from a deprotonated azo form to a hydrazone form in a strongly acidic environment to realize fluorescence light-up behavior, thus monitoring the lower lysosomal pH of cancer cells and distinguishing them from normal cells | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Fluorescent Dyes |2 NLM | |
| 650 | 7 | |a Hydrazones |2 NLM | |
| 650 | 7 | |a Protons |2 NLM | |
| 700 | 1 | |a Yan, Chenxu |e verfasserin |4 aut | |
| 700 | 1 | |a Qiu, Wan-Shan |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Tao |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Wu-Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Wei-Hong |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Chemical communications (Cambridge, England) |d 1998 |g 58(2022), 76 vom: 22. Sept., Seite 10635-10638 |w (DE-627)NLM095512322 |x 1364-548X |7 nnns |
| 773 | 1 | 8 | |g volume:58 |g year:2022 |g number:76 |g day:22 |g month:09 |g pages:10635-10638 |
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