Evaluation of cellular stress responses in magnetomotive ultrasound
Early and accurate diagnoses are important for successful cancer treatment. Lymph node involvement is often critical, and magnetomotive ultrasound (MMUS) has been proposed for its detection and characterization. MMUS relies on a magnetic contrast agent, for example, iron oxide nanoparticles, delivered to the tissue of interest, magnetically set in motion and detected using ultrasound. The magneto-mechanical interaction has not previously been evaluated on a cellular level. Here we demonstrate uptake and dose-dependent retention of magnetic nanoparticles in two human adenocarcinoma cell lines, with <10% cytotoxicity which did not increase following magnetic excitation. Further, the oxidative stress levels were not affected by magnetic particles or force. Thus, we found no evidence of adverse effects from the magneto-mechanical interactions under these conditions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Nanomedicine (London, England) - 17(2022), 14 vom: 31. Juni, Seite 1013-1025 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sjöstrand, Sandra [VerfasserIn] |
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| Links: |
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| Themen: |
Caco-2 |
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| Anmerkungen: |
Date Completed 20.10.2022 Date Revised 26.10.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.2217/nnm-2021-0455 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM345612582 |
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| 520 | |a Early and accurate diagnoses are important for successful cancer treatment. Lymph node involvement is often critical, and magnetomotive ultrasound (MMUS) has been proposed for its detection and characterization. MMUS relies on a magnetic contrast agent, for example, iron oxide nanoparticles, delivered to the tissue of interest, magnetically set in motion and detected using ultrasound. The magneto-mechanical interaction has not previously been evaluated on a cellular level. Here we demonstrate uptake and dose-dependent retention of magnetic nanoparticles in two human adenocarcinoma cell lines, with <10% cytotoxicity which did not increase following magnetic excitation. Further, the oxidative stress levels were not affected by magnetic particles or force. Thus, we found no evidence of adverse effects from the magneto-mechanical interactions under these conditions | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Stephanie Zeller, Kathrin |e verfasserin |4 aut | |
| 700 | 1 | |a Evertsson, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Jansson, Tomas |e verfasserin |4 aut | |
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