Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis
© 2022. The Author(s)..
Transmission-driven multi-/extensively drug resistant (M/XDR) tuberculosis (TB) is the largest single contributor to human mortality due to antimicrobial resistance. A few major clades of the Mycobacterium tuberculosis complex belonging to lineage 2, responsible for high prevalence of MDR-TB in Eurasia, show outstanding transnational distributions. Here, we determined factors underlying the emergence and epidemic spread of the W148 clade by genome sequencing and Bayesian demogenetic analyses of 720 isolates from 23 countries. We dated a common ancestor around 1963 and identified two successive epidemic expansions in the late 1980s and late 1990s, coinciding with major socio-economic changes in the post-Soviet Era. These population expansions favored accumulation of resistance mutations to up to 11 anti-TB drugs, with MDR evolving toward additional resistances to fluoroquinolones and second-line injectable drugs within 20 years on average. Timescaled haplotypic density analysis revealed that widespread acquisition of compensatory mutations was associated with transmission success of XDR strains. Virtually all W148 strains harbored a hypervirulence-associated ppe38 gene locus, and incipient recurrent emergence of prpR mutation-mediated drug tolerance was detected. The outstanding genetic arsenal of this geographically widespread M/XDR strain clade represents a "perfect storm" that jeopardizes the successful introduction of new anti-M/XDR-TB antibiotic regimens.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
|---|---|
| Enthalten in: |
Nature communications - 13(2022), 1 vom: 30. Aug., Seite 5105 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Merker, Matthias [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Antitubercular Agents |
|---|
| Anmerkungen: |
Date Completed 02.09.2022 Date Revised 26.09.2022 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1038/s41467-022-32455-1 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM345595688 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM345595688 | ||
| 003 | DE-627 | ||
| 005 | 20231226025424.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41467-022-32455-1 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1151.xml |
| 035 | |a (DE-627)NLM345595688 | ||
| 035 | |a (NLM)36042200 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Merker, Matthias |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 02.09.2022 | ||
| 500 | |a Date Revised 26.09.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. The Author(s). | ||
| 520 | |a Transmission-driven multi-/extensively drug resistant (M/XDR) tuberculosis (TB) is the largest single contributor to human mortality due to antimicrobial resistance. A few major clades of the Mycobacterium tuberculosis complex belonging to lineage 2, responsible for high prevalence of MDR-TB in Eurasia, show outstanding transnational distributions. Here, we determined factors underlying the emergence and epidemic spread of the W148 clade by genome sequencing and Bayesian demogenetic analyses of 720 isolates from 23 countries. We dated a common ancestor around 1963 and identified two successive epidemic expansions in the late 1980s and late 1990s, coinciding with major socio-economic changes in the post-Soviet Era. These population expansions favored accumulation of resistance mutations to up to 11 anti-TB drugs, with MDR evolving toward additional resistances to fluoroquinolones and second-line injectable drugs within 20 years on average. Timescaled haplotypic density analysis revealed that widespread acquisition of compensatory mutations was associated with transmission success of XDR strains. Virtually all W148 strains harbored a hypervirulence-associated ppe38 gene locus, and incipient recurrent emergence of prpR mutation-mediated drug tolerance was detected. The outstanding genetic arsenal of this geographically widespread M/XDR strain clade represents a "perfect storm" that jeopardizes the successful introduction of new anti-M/XDR-TB antibiotic regimens | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Antitubercular Agents |2 NLM | |
| 700 | 1 | |a Rasigade, Jean-Philippe |e verfasserin |4 aut | |
| 700 | 1 | |a Barbier, Maxime |e verfasserin |4 aut | |
| 700 | 1 | |a Cox, Helen |e verfasserin |4 aut | |
| 700 | 1 | |a Feuerriegel, Silke |e verfasserin |4 aut | |
| 700 | 1 | |a Kohl, Thomas A |e verfasserin |4 aut | |
| 700 | 1 | |a Shitikov, Egor |e verfasserin |4 aut | |
| 700 | 1 | |a Klaos, Kadri |e verfasserin |4 aut | |
| 700 | 1 | |a Gaudin, Cyril |e verfasserin |4 aut | |
| 700 | 1 | |a Antoine, Rudy |e verfasserin |4 aut | |
| 700 | 1 | |a Diel, Roland |e verfasserin |4 aut | |
| 700 | 1 | |a Borrell, Sonia |e verfasserin |4 aut | |
| 700 | 1 | |a Gagneux, Sebastien |e verfasserin |4 aut | |
| 700 | 1 | |a Nikolayevskyy, Vladyslav |e verfasserin |4 aut | |
| 700 | 1 | |a Andres, Sönke |e verfasserin |4 aut | |
| 700 | 1 | |a Crudu, Valeriu |e verfasserin |4 aut | |
| 700 | 1 | |a Supply, Philip |e verfasserin |4 aut | |
| 700 | 1 | |a Niemann, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Wirth, Thierry |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature communications |d 2010 |g 13(2022), 1 vom: 30. Aug., Seite 5105 |w (DE-627)NLM199274525 |x 2041-1723 |7 nnns |
| 773 | 1 | 8 | |g volume:13 |g year:2022 |g number:1 |g day:30 |g month:08 |g pages:5105 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41467-022-32455-1 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 13 |j 2022 |e 1 |b 30 |c 08 |h 5105 | ||