Evaluation of the effectiveness of treatment of patients with nonspecific pain syndrome in the lower back with celecoxib and a combined preparation of B vitamins
OBJECTIVE: To evaluate the effectiveness of the effect of celecoxib and the combined vitamin complex of group B in comparison with meloxicam in patients with acute and chronic nonspecific lumbar pain (LP).
MATERIAL AND METHODS: The effectiveness of the effect on acute (44%; acute pain syndrome (APS)) and chronic (56%; chronic pain syndrome (CPS)) LP of moderate intensity (according to VAS/MPQ) (APS 5.7±2.3/2.13±0.67 points; CPS 5.2±2.8/1.47±0.61 points), the leading component of which is sensory sensations (when APS is lower than in CBS; Kr-W=6.15, p=0.04) and affective disorders in CPS (U=117.5, p=0.04) celecoxib without (APS 25%; CPS 75%) and with the addition of Neuromultivit (APS 36%; CPS 64%) and in comparison with meloxicam (APS 100%) against the background of basic therapy in 93 patients (61.3% women and 38.7% men; average age 49.9±9. years) with nonspecific LP pain syndrome in the lower back, with a low degree of severity of motor function (MF) disorders according to the ICF (2±1 points), due to spondyloarthrosis of the lumbosacral spine.
RESULTS: It was found that celecoxib and meloxicam cause the same significant remitting decrease in the severity of APS and restoration of MF disorders in patients with APS, equally cause rare adverse events (gastropathy, increased blood pressure) in comorbid pathology. Celecoxib proved to be more effective in relieving CPS and improving MF (p<0.05), and the combination of celecoxib with Neuromultivit caused more pronounced relief of APS and CPS, restoration of MF (p<0.01). A steady decrease in the intensity of PS (1-2 points according to VAS), recovery of MF occurs only on the 10th-11th day of therapy (p<0.01), with complete relief of LP by day 21 only in 60.22% of cases.
CONCLUSION: The results of the study confirm the benefits of celecoxib in combination with a vitamin complex for the relief of CPS.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:122 |
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| Enthalten in: |
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova - 122(2022), 8 vom: 28., Seite 65-72 |
| Sprache: |
Russisch |
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| Weiterer Titel: |
Otsenka effektivnosti lecheniya patsientov s nespetsificheskim bolevym sindromom v poyasnitse tselekoksibom i kombinirovannym preparatom vitaminov gruppy B |
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| Beteiligte Personen: |
Antonen, E G [VerfasserIn] |
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| Links: |
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| Themen: |
12001-76-2 |
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| Anmerkungen: |
Date Completed 30.08.2022 Date Revised 30.08.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.17116/jnevro202212208165 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM345538331 |
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| 245 | 1 | 0 | |a Evaluation of the effectiveness of treatment of patients with nonspecific pain syndrome in the lower back with celecoxib and a combined preparation of B vitamins |
| 246 | 3 | 3 | |a Otsenka effektivnosti lecheniya patsientov s nespetsificheskim bolevym sindromom v poyasnitse tselekoksibom i kombinirovannym preparatom vitaminov gruppy B |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 30.08.2022 | ||
| 500 | |a Date Revised 30.08.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To evaluate the effectiveness of the effect of celecoxib and the combined vitamin complex of group B in comparison with meloxicam in patients with acute and chronic nonspecific lumbar pain (LP) | ||
| 520 | |a MATERIAL AND METHODS: The effectiveness of the effect on acute (44%; acute pain syndrome (APS)) and chronic (56%; chronic pain syndrome (CPS)) LP of moderate intensity (according to VAS/MPQ) (APS 5.7±2.3/2.13±0.67 points; CPS 5.2±2.8/1.47±0.61 points), the leading component of which is sensory sensations (when APS is lower than in CBS; Kr-W=6.15, p=0.04) and affective disorders in CPS (U=117.5, p=0.04) celecoxib without (APS 25%; CPS 75%) and with the addition of Neuromultivit (APS 36%; CPS 64%) and in comparison with meloxicam (APS 100%) against the background of basic therapy in 93 patients (61.3% women and 38.7% men; average age 49.9±9. years) with nonspecific LP pain syndrome in the lower back, with a low degree of severity of motor function (MF) disorders according to the ICF (2±1 points), due to spondyloarthrosis of the lumbosacral spine | ||
| 520 | |a RESULTS: It was found that celecoxib and meloxicam cause the same significant remitting decrease in the severity of APS and restoration of MF disorders in patients with APS, equally cause rare adverse events (gastropathy, increased blood pressure) in comorbid pathology. Celecoxib proved to be more effective in relieving CPS and improving MF (p<0.05), and the combination of celecoxib with Neuromultivit caused more pronounced relief of APS and CPS, restoration of MF (p<0.01). A steady decrease in the intensity of PS (1-2 points according to VAS), recovery of MF occurs only on the 10th-11th day of therapy (p<0.01), with complete relief of LP by day 21 only in 60.22% of cases | ||
| 520 | |a CONCLUSION: The results of the study confirm the benefits of celecoxib in combination with a vitamin complex for the relief of CPS | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a B vitamins | |
| 650 | 4 | |a Neuromultivit | |
| 650 | 4 | |a acute and chronic pain | |
| 650 | 4 | |a celecoxib | |
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| 700 | 1 | |a Nikitina, M V |e verfasserin |4 aut | |
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