A new indicator : The diagnostic value of CD8+T/B lymphocyte ratio in sepsis progression
OBJECTIVE: To reveal the value of single lymphocyte subpopulation and their ratios in the progression of sepsis.
METHODS: From January 2019 to March 2021, 39 sepsis patients, 16 septic shock patients, and 50 healthy volunteers were recruited in the Second Xiangya Hospital for this cross-sectional study. The absolute quantitation of CD4+T, CD8+T, B lymphocytes, and NK cells in peripheral blood were determined by flow cytometry. SPSS Software was used to analyze the results.
RESULTS: On the whole, the numbers of lymphocytes in the sepsis group and in the septic shock group were lower than that in the healthy control group. Surprisingly, the percentage of CD8+T lymphocytes in the septic shock group was slightly higher than that in the sepsis group. The percentage of B lymphocytes in the sepsis group was higher than that in the healthy control group. The AUC of CD8+T/B was 0.724, with the sensitivity and specificity being 75.00% and 71.79%, respectively.
CONCLUSION: The immune expression pattern of patients with sepsis was not a simple decrease in the number of lymphocytes. The change in the ratios of lymphocyte subpopulation might be more meaningful along the development and progression of sepsis. The ratio of CD8+T/B could be used to diagnose the progression of sepsis and reduce the misdiagnosis rate to a certain extent.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
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Enthalten in: |
International journal of immunopathology and pharmacology - 36(2022) vom: 20. Jan., Seite 3946320221123164 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Peng, Yizhi [VerfasserIn] |
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Links: |
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Themen: |
Diagnosis |
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Anmerkungen: |
Date Completed 30.08.2022 Date Revised 02.09.2022 published: Print Citation Status MEDLINE |
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doi: |
10.1177/03946320221123164 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM345535871 |
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100 | 1 | |a Peng, Yizhi |e verfasserin |4 aut | |
245 | 1 | 2 | |a A new indicator |b The diagnostic value of CD8+T/B lymphocyte ratio in sepsis progression |
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500 | |a Date Completed 30.08.2022 | ||
500 | |a Date Revised 02.09.2022 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a OBJECTIVE: To reveal the value of single lymphocyte subpopulation and their ratios in the progression of sepsis | ||
520 | |a METHODS: From January 2019 to March 2021, 39 sepsis patients, 16 septic shock patients, and 50 healthy volunteers were recruited in the Second Xiangya Hospital for this cross-sectional study. The absolute quantitation of CD4+T, CD8+T, B lymphocytes, and NK cells in peripheral blood were determined by flow cytometry. SPSS Software was used to analyze the results | ||
520 | |a RESULTS: On the whole, the numbers of lymphocytes in the sepsis group and in the septic shock group were lower than that in the healthy control group. Surprisingly, the percentage of CD8+T lymphocytes in the septic shock group was slightly higher than that in the sepsis group. The percentage of B lymphocytes in the sepsis group was higher than that in the healthy control group. The AUC of CD8+T/B was 0.724, with the sensitivity and specificity being 75.00% and 71.79%, respectively | ||
520 | |a CONCLUSION: The immune expression pattern of patients with sepsis was not a simple decrease in the number of lymphocytes. The change in the ratios of lymphocyte subpopulation might be more meaningful along the development and progression of sepsis. The ratio of CD8+T/B could be used to diagnose the progression of sepsis and reduce the misdiagnosis rate to a certain extent | ||
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700 | 1 | |a Yin, Sheng |e verfasserin |4 aut | |
700 | 1 | |a Wang, Min |e verfasserin |4 aut | |
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