Design of erythrocyte-derived carriers for bioimaging applications
Copyright © 2022 Elsevier Ltd. All rights reserved..
Erythrocytes are physiological entities that have been exploited in both preclinical and clinical trials for the delivery of exogenous agents. Over the years, diverse erythrocyte-derived carriers (ECs) have been developed with related patents granted for industrial and commercial purposes. However, most ECs have only been exploited for drug delivery. Serious discussions regarding their applications in imaging are scarce. This article reviews the role of ECs in enhancing imaging efficiency and subsequently delineates strategies for engineering and optimising their preclinical and clinical performance. With a snapshot of the latest developments and use of ECs in imaging, directions to streamline the clinical translation of related technologies can be attained for future research.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
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| Enthalten in: |
Trends in biotechnology - 41(2023), 2 vom: 25. Feb., Seite 228-241 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lai, Wing-Fu [VerfasserIn] |
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| Links: |
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| Themen: |
Biodistribution |
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| Anmerkungen: |
Date Completed 23.01.2023 Date Revised 07.03.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.tibtech.2022.07.010 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM345489241 |
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| 520 | |a Erythrocytes are physiological entities that have been exploited in both preclinical and clinical trials for the delivery of exogenous agents. Over the years, diverse erythrocyte-derived carriers (ECs) have been developed with related patents granted for industrial and commercial purposes. However, most ECs have only been exploited for drug delivery. Serious discussions regarding their applications in imaging are scarce. This article reviews the role of ECs in enhancing imaging efficiency and subsequently delineates strategies for engineering and optimising their preclinical and clinical performance. With a snapshot of the latest developments and use of ECs in imaging, directions to streamline the clinical translation of related technologies can be attained for future research | ||
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