A Fully Implantable Opto-Electro Closed-Loop Neural Interface for Motor Neuron Disease Studies
This paper presents a fully implantable closed-loop device for use in freely moving rodents to investigate new treatments for motor neuron disease. The 0.18 μm CMOS integrated circuit comprises 4 stimulators, each featuring 16 channels for optical and electrical stimulation using arbitrary current waveforms at frequencies from 1.5 Hz to 50 kHz, and a bandwidth programmable front-end for neural recording. The implant uses a Qi wireless inductive link which can deliver >100 mW power at a maximum distance of 2 cm for a freely moving rodent. A backup rechargeable battery can support 10 mA continuous stimulation currents for 2.5 hours in the absence of an inductive power link. The implant is controlled by a graphic user interface with broad programmable parameters via a Bluetooth low energy bidirectional data telemetry link. The encapsulated implant is 40 mm × 20 mm × 10 mm. Measured results are presented showing the electrical performance of the electronics and the packaging method.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
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| Enthalten in: |
IEEE transactions on biomedical circuits and systems - 16(2022), 5 vom: 01. Okt., Seite 752-765 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Fangqi [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 02.12.2022 Date Revised 22.03.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1109/TBCAS.2022.3202026 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM345372581 |
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| 520 | |a This paper presents a fully implantable closed-loop device for use in freely moving rodents to investigate new treatments for motor neuron disease. The 0.18 μm CMOS integrated circuit comprises 4 stimulators, each featuring 16 channels for optical and electrical stimulation using arbitrary current waveforms at frequencies from 1.5 Hz to 50 kHz, and a bandwidth programmable front-end for neural recording. The implant uses a Qi wireless inductive link which can deliver >100 mW power at a maximum distance of 2 cm for a freely moving rodent. A backup rechargeable battery can support 10 mA continuous stimulation currents for 2.5 hours in the absence of an inductive power link. The implant is controlled by a graphic user interface with broad programmable parameters via a Bluetooth low energy bidirectional data telemetry link. The encapsulated implant is 40 mm × 20 mm × 10 mm. Measured results are presented showing the electrical performance of the electronics and the packaging method | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Wu, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Almarri, Noora |e verfasserin |4 aut | |
| 700 | 1 | |a Habibollahi, Maryam |e verfasserin |4 aut | |
| 700 | 1 | |a Lancashire, Henry Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Bryson, Barney |e verfasserin |4 aut | |
| 700 | 1 | |a Greensmith, Linda |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Dai |e verfasserin |4 aut | |
| 700 | 1 | |a Demosthenous, Andreas |e verfasserin |4 aut | |
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