Chemistry, Biosynthesis and Pharmacology of Viniferin : Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy
Viniferin is a resveratrol derivative. Resveratrol is the most prominent stilbenoid synthesized by plants as a defense mechanism in response to microbial attack, toxins, infections or UV radiation. Different forms of viniferin exist, including alpha-viniferin (α-viniferin), beta-viniferin (β-viniferin), delta-viniferin (δ-viniferin), epsilon-viniferin (ε-viniferin), gamma-viniferin (γ-viniferin), R-viniferin (vitisin A), and R2-viniferin (vitisin B). All of these forms exhibit a range of important biological activities and, therefore, have several possible applications in clinical research and future drug development. In this review, we present a comprehensive literature search on the chemistry and biosynthesis of and the diverse studies conducted on viniferin, especially with regards to its anti-inflammatory, antipsoriasis, antidiabetic, antiplasmodic, anticancer, anti-angiogenic, antioxidant, anti-melanogenic, neurodegenerative effects, antiviral, antimicrobial, antifungal, antidiarrhea, anti-obesity and anthelminthic activities. In addition to highlighting its important chemical and biological activities, coherent and environmentally acceptable methods for establishing vinferin on a large scale are highlighted to allow the development of further research that can help to exploit its properties and develop new phyto-pharmaceuticals. Overall, viniferin and its derivatives have the potential to be the most effective nutritional supplement and supplementary medication, especially as a therapeutic approach. More researchers will be aware of viniferin as a pharmaceutical drug as a consequence of this review, and they will be encouraged to investigate viniferin and its derivatives as pharmaceutical drugs to prevent future health catastrophes caused by a variety of serious illnesses.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
|---|---|
| Enthalten in: |
Molecules (Basel, Switzerland) - 27(2022), 16 vom: 09. Aug. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Fuloria, Shivkanya [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Antioxidants |
|---|
| Anmerkungen: |
Date Completed 29.08.2022 Date Revised 30.08.2022 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.3390/molecules27165072 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM345327020 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM345327020 | ||
| 003 | DE-627 | ||
| 005 | 20231226024822.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/molecules27165072 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1151.xml |
| 035 | |a (DE-627)NLM345327020 | ||
| 035 | |a (NLM)36014304 | ||
| 035 | |a (PII)5072 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Fuloria, Shivkanya |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Chemistry, Biosynthesis and Pharmacology of Viniferin |b Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 29.08.2022 | ||
| 500 | |a Date Revised 30.08.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Viniferin is a resveratrol derivative. Resveratrol is the most prominent stilbenoid synthesized by plants as a defense mechanism in response to microbial attack, toxins, infections or UV radiation. Different forms of viniferin exist, including alpha-viniferin (α-viniferin), beta-viniferin (β-viniferin), delta-viniferin (δ-viniferin), epsilon-viniferin (ε-viniferin), gamma-viniferin (γ-viniferin), R-viniferin (vitisin A), and R2-viniferin (vitisin B). All of these forms exhibit a range of important biological activities and, therefore, have several possible applications in clinical research and future drug development. In this review, we present a comprehensive literature search on the chemistry and biosynthesis of and the diverse studies conducted on viniferin, especially with regards to its anti-inflammatory, antipsoriasis, antidiabetic, antiplasmodic, anticancer, anti-angiogenic, antioxidant, anti-melanogenic, neurodegenerative effects, antiviral, antimicrobial, antifungal, antidiarrhea, anti-obesity and anthelminthic activities. In addition to highlighting its important chemical and biological activities, coherent and environmentally acceptable methods for establishing vinferin on a large scale are highlighted to allow the development of further research that can help to exploit its properties and develop new phyto-pharmaceuticals. Overall, viniferin and its derivatives have the potential to be the most effective nutritional supplement and supplementary medication, especially as a therapeutic approach. More researchers will be aware of viniferin as a pharmaceutical drug as a consequence of this review, and they will be encouraged to investigate viniferin and its derivatives as pharmaceutical drugs to prevent future health catastrophes caused by a variety of serious illnesses | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a biosynthesis | |
| 650 | 4 | |a chemistry | |
| 650 | 4 | |a drug discovery | |
| 650 | 4 | |a oligostilbenoid | |
| 650 | 4 | |a pharmacology | |
| 650 | 4 | |a viniferin | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Antiviral Agents |2 NLM | |
| 650 | 7 | |a Pharmaceutical Preparations |2 NLM | |
| 650 | 7 | |a Stilbenes |2 NLM | |
| 650 | 7 | |a Resveratrol |2 NLM | |
| 650 | 7 | |a Q369O8926L |2 NLM | |
| 700 | 1 | |a Sekar, Mahendran |e verfasserin |4 aut | |
| 700 | 1 | |a Khattulanuar, Farrah Syazana |e verfasserin |4 aut | |
| 700 | 1 | |a Gan, Siew Hua |e verfasserin |4 aut | |
| 700 | 1 | |a Rani, Nur Najihah Izzati Mat |e verfasserin |4 aut | |
| 700 | 1 | |a Ravi, Subban |e verfasserin |4 aut | |
| 700 | 1 | |a Subramaniyan, Vetriselvan |e verfasserin |4 aut | |
| 700 | 1 | |a Jeyabalan, Srikanth |e verfasserin |4 aut | |
| 700 | 1 | |a Begum, M Yasmin |e verfasserin |4 aut | |
| 700 | 1 | |a Chidambaram, Kumarappan |e verfasserin |4 aut | |
| 700 | 1 | |a Sathasivam, Kathiresan V |e verfasserin |4 aut | |
| 700 | 1 | |a Safi, Sher Zaman |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Yuan Seng |e verfasserin |4 aut | |
| 700 | 1 | |a Nordin, Rusli |e verfasserin |4 aut | |
| 700 | 1 | |a Maziz, Mohammad Nazmul Hasan |e verfasserin |4 aut | |
| 700 | 1 | |a Kumarasamy, Vinoth |e verfasserin |4 aut | |
| 700 | 1 | |a Lum, Pei Teng |e verfasserin |4 aut | |
| 700 | 1 | |a Fuloria, Neeraj Kumar |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Molecules (Basel, Switzerland) |d 2004 |g 27(2022), 16 vom: 09. Aug. |w (DE-627)NLM172073448 |x 1420-3049 |7 nnns |
| 773 | 1 | 8 | |g volume:27 |g year:2022 |g number:16 |g day:09 |g month:08 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3390/molecules27165072 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 27 |j 2022 |e 16 |b 09 |c 08 | ||