Molecular Approach for the Laboratory Diagnosis of Periprosthetic Joint Infections
The incidence of total joint arthroplasty is increasing over time since the last decade and expected to be more than 4 million by 2030. As a consequence, the detection of infections associated with surgical interventions is increasing and prosthetic joint infections are representing both a clinically and economically challenging problem. Many pathogens, from bacteria to fungi, elicit the immune system response and produce a polymeric matrix, the biofilm, that serves as their protection. In the last years, the implementation of diagnostic methodologies reduced the error rate and the turn-around time: polymerase chain reaction, targeted or broad-spectrum, and next-generation sequencing have been introduced and they represent a robust approach nowadays that frees laboratories from the unique approach based on culture-based techniques.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Microorganisms - 10(2022), 8 vom: 05. Aug. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gatti, Giulia [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Revised 30.08.2022 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/microorganisms10081573 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM345323858 |
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| 520 | |a The incidence of total joint arthroplasty is increasing over time since the last decade and expected to be more than 4 million by 2030. As a consequence, the detection of infections associated with surgical interventions is increasing and prosthetic joint infections are representing both a clinically and economically challenging problem. Many pathogens, from bacteria to fungi, elicit the immune system response and produce a polymeric matrix, the biofilm, that serves as their protection. In the last years, the implementation of diagnostic methodologies reduced the error rate and the turn-around time: polymerase chain reaction, targeted or broad-spectrum, and next-generation sequencing have been introduced and they represent a robust approach nowadays that frees laboratories from the unique approach based on culture-based techniques | ||
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| 700 | 1 | |a Brandolini, Martina |e verfasserin |4 aut | |
| 700 | 1 | |a Mancini, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Denicolò, Agnese |e verfasserin |4 aut | |
| 700 | 1 | |a Congestrì, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Manera, Martina |e verfasserin |4 aut | |
| 700 | 1 | |a Arfilli, Valentina |e verfasserin |4 aut | |
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| 700 | 1 | |a Marino, Maria Michela |e verfasserin |4 aut | |
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| 700 | 1 | |a Cricca, Monica |e verfasserin |4 aut | |
| 700 | 1 | |a Sambri, Vittorio |e verfasserin |4 aut | |
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