Buprenorphine and its formulations : a comprehensive review
Buprenorphine, a novel long-acting analgesic, was developed with the intention of two purposes: analgesia and opioid use disorder. Regarding its pharmacodynamics, it is a partial agonist at mu receptors, an inverse agonist at kappa receptors, and an antagonist at delta receptors. For the purpose of analgesia, three formulations of buprenorphine were developed: IV/IM injectable formulation (Buprenex®), transdermal patch formulation (Butrans®), and buccal film formulation (Belbuca®). Related to opioid dependence, the formulations developed were subcutaneous extended release (Sublocade®), subdermal implant (Probuphine®), and sublingual tablets (Subutex®). Lastly, in order to avoid misuse of buprenorphine for opioid dependence, two combination formulations paired with naloxone were developed: film formulation (Suboxone®) and tablet formulation (Zubsolv®). In this review, we present details of each formulation along with their similarities and differences between each other and clinical considerations.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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Enthalten in: |
Health psychology research - 10(2022), 3 vom: 20., Seite 37517 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Poliwoda, Salomon [VerfasserIn] |
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Links: |
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Themen: |
Analgesic |
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Anmerkungen: |
Date Revised 26.08.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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doi: |
10.52965/001c.37517 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM345184491 |
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