The role of paraoxonase and myeloperoxidase as oxidative stress markers in pregnant women with hypothyroidism
Objective: This study aims to measure paraoxonase 1 (PON 1) and myeloperoxidase (MPO) levels in patients diagnosed with hypothyroidism during pregnancy by spectrophotometric method and to compare the results with healthy controls. Methods: For the study, the blood samples of 45 hypothyroid pregnant patients and 45 healthy control pregnant individuals who were compatible with the patient group in terms of age were taken. PON 1 and MPO levels in both groups were measured using spectrophotometric methods and statistical analysis was performed. Results: Serum PON 1 activity levels were significantly lower in hypothyroid pregnant patients than in the control group (p=.020). The patients group had significantly higher serum MPO concentrations than in control group (p=.020). MPO/PON-1 ratio was higher in pregnant patients with hypothyroidism than in the control group (p=.030). Conclusion: Decreased levels of PON1 with increased levels of MPO in hypothyroid pregnant patients suggest the critical role of oxidative stress in hypothyroidism during pregnancy.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:38 |
|---|---|
| Enthalten in: |
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology - 38(2022), 10 vom: 06. Okt., Seite 840-843 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Cakina, Suat [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
妊娠 |
|---|
| Anmerkungen: |
Date Completed 11.11.2022 Date Revised 11.11.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1080/09513590.2022.2114449 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM345181824 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM345181824 | ||
| 003 | DE-627 | ||
| 005 | 20231226024501.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/09513590.2022.2114449 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1150.xml |
| 035 | |a (DE-627)NLM345181824 | ||
| 035 | |a (NLM)35999709 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Cakina, Suat |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The role of paraoxonase and myeloperoxidase as oxidative stress markers in pregnant women with hypothyroidism |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 11.11.2022 | ||
| 500 | |a Date Revised 11.11.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Objective: This study aims to measure paraoxonase 1 (PON 1) and myeloperoxidase (MPO) levels in patients diagnosed with hypothyroidism during pregnancy by spectrophotometric method and to compare the results with healthy controls. Methods: For the study, the blood samples of 45 hypothyroid pregnant patients and 45 healthy control pregnant individuals who were compatible with the patient group in terms of age were taken. PON 1 and MPO levels in both groups were measured using spectrophotometric methods and statistical analysis was performed. Results: Serum PON 1 activity levels were significantly lower in hypothyroid pregnant patients than in the control group (p=.020). The patients group had significantly higher serum MPO concentrations than in control group (p=.020). MPO/PON-1 ratio was higher in pregnant patients with hypothyroidism than in the control group (p=.030). Conclusion: Decreased levels of PON1 with increased levels of MPO in hypothyroid pregnant patients suggest the critical role of oxidative stress in hypothyroidism during pregnancy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a hypothyroidism | |
| 650 | 4 | |a myeloperoxidase | |
| 650 | 4 | |a paraoxonase | |
| 650 | 4 | |a pregnancy | |
| 650 | 4 | |a 妊娠 | |
| 650 | 4 | |a 对氧磷酶 | |
| 650 | 4 | |a 甲状腺功能减退症 | |
| 650 | 4 | |a 髓过氧化物酶 | |
| 650 | 7 | |a Aryldialkylphosphatase |2 NLM | |
| 650 | 7 | |a EC 3.1.8.1 |2 NLM | |
| 650 | 7 | |a Peroxidase |2 NLM | |
| 650 | 7 | |a EC 1.11.1.7 |2 NLM | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a PON1 protein, human |2 NLM | |
| 650 | 7 | |a EC 3.1.8.1 |2 NLM | |
| 700 | 1 | |a Pek, Eren |e verfasserin |4 aut | |
| 700 | 1 | |a Ozkavak, Onur |e verfasserin |4 aut | |
| 700 | 1 | |a Kocyigit, Deniz |e verfasserin |4 aut | |
| 700 | 1 | |a Beyazıt, Fatma |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology |d 1996 |g 38(2022), 10 vom: 06. Okt., Seite 840-843 |w (DE-627)NLM013051202 |x 1473-0766 |7 nnns |
| 773 | 1 | 8 | |g volume:38 |g year:2022 |g number:10 |g day:06 |g month:10 |g pages:840-843 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/09513590.2022.2114449 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 38 |j 2022 |e 10 |b 06 |c 10 |h 840-843 | ||