Angiotensin-(1-7) attenuates the negative inotropic response to acetylcholine in the heart
Copyright © 2022. Published by Elsevier Inc..
Previous studies have suggested that the Angiotensin-(1-7) [(Ang-(1-7)] can change cardiac function by modulating the autonomic nervous system. However, it is unknown whether the Ang-(1-7) can modulate the effect of acetylcholine (ACh) in ventricular contractility. Thus, this study aimed to investigate whether Ang-(1-7) modifies the amplitude of the cardiac cholinergic effects and if these effects are intrinsic to the heart. In anesthetized Wistar rats, Ang-(1-7) attenuated the effect of ACh in decreasing the left ventricular end-systolic pressure (LVESP), dP/dtmax, and dP/dtmin, but did not modify the hypotensive effect of ACh. Similarly, Ang-(1-7) attenuated the reduction of the LVESP, dP/dtmax, and dP/dtmin evoked by ACh in isolated hearts. These effects were blocked by the Mas receptor antagonist, A-779, but not by the adenylyl cyclase inhibitor MDL-12,330 A. Ang-(1-7) also attenuated the reduction in the maximum contraction and relaxation speeds and the shortening promoted by ACh in isolated cardiomyocytes. These data show that Ang-(1-7) acting through Mas receptor counter-regulates the myocardial contractile response to ACh in an arterial pressure and heart rate-independent manner.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:158 |
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| Enthalten in: |
Peptides - 158(2022) vom: 15. Dez., Seite 170862 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Pontes, Carolina Nobre Ribeiro [VerfasserIn] |
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| Links: |
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| Themen: |
11128-99-7 |
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| Anmerkungen: |
Date Completed 29.11.2022 Date Revised 07.02.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.peptides.2022.170862 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM345172019 |
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| 520 | |a Previous studies have suggested that the Angiotensin-(1-7) [(Ang-(1-7)] can change cardiac function by modulating the autonomic nervous system. However, it is unknown whether the Ang-(1-7) can modulate the effect of acetylcholine (ACh) in ventricular contractility. Thus, this study aimed to investigate whether Ang-(1-7) modifies the amplitude of the cardiac cholinergic effects and if these effects are intrinsic to the heart. In anesthetized Wistar rats, Ang-(1-7) attenuated the effect of ACh in decreasing the left ventricular end-systolic pressure (LVESP), dP/dtmax, and dP/dtmin, but did not modify the hypotensive effect of ACh. Similarly, Ang-(1-7) attenuated the reduction of the LVESP, dP/dtmax, and dP/dtmin evoked by ACh in isolated hearts. These effects were blocked by the Mas receptor antagonist, A-779, but not by the adenylyl cyclase inhibitor MDL-12,330 A. Ang-(1-7) also attenuated the reduction in the maximum contraction and relaxation speeds and the shortening promoted by ACh in isolated cardiomyocytes. These data show that Ang-(1-7) acting through Mas receptor counter-regulates the myocardial contractile response to ACh in an arterial pressure and heart rate-independent manner | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acetylcholine | |
| 650 | 4 | |a Cardiac function | |
| 650 | 4 | |a Mas receptor | |
| 650 | 4 | |a Renin-Angiotensin System | |
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| 650 | 7 | |a Angiotensin II |2 NLM | |
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| 700 | 1 | |a Scalzo, Sérgio |e verfasserin |4 aut | |
| 700 | 1 | |a Jesus, Itamar Couto Guedes |e verfasserin |4 aut | |
| 700 | 1 | |a Jesus, Erika Fernandes de |e verfasserin |4 aut | |
| 700 | 1 | |a Nunes, Allancer Divino de Carvalho |e verfasserin |4 aut | |
| 700 | 1 | |a Mendonça, Michelle Mendanha |e verfasserin |4 aut | |
| 700 | 1 | |a Mendes, Elizabeth Pereira |e verfasserin |4 aut | |
| 700 | 1 | |a Colugnati, Diego Basile |e verfasserin |4 aut | |
| 700 | 1 | |a Xavier, Carlos Henrique |e verfasserin |4 aut | |
| 700 | 1 | |a Pedrino, Gustavo Rodrigues |e verfasserin |4 aut | |
| 700 | 1 | |a Guatimosim, Silvia |e verfasserin |4 aut | |
| 700 | 1 | |a Castro, Carlos Henrique |e verfasserin |4 aut | |
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