Evaluation of the Boson rapid Ag test vs RT-PCR for use as a self-testing platform
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved..
The gold standard test available for detecting COVID-19 patients is Real Time RT-PCR. However, this method is expensive, needing special equipment and skilled laboratory staff. Recently, less expensive antigen tests have become available, that could easily and rapidly identify new COVID-19 cases. Our objective was to evaluate the Boson Rapid Antigen Test Card versus the RT-rtPCR, using samples taken both by laymen (self-testing) and professionals. The sensitivity, specificity and accuracy rates were, 98.18%, 100.00%, and 99.28%, respectively. The positive and negative predictive values were 100.00% and 98.82%, respectively. The detection rate for asymptomatic patients was 90.48%, and detection rate for Ct values ≥30 was 91.67%. Our results indicate a high coincidence rate between the Boson and the referencing RT-rtPCR method, meeting the performance standards recommended by the WHO. Therefore, this test could facilitate a fast self-testing screening method, for the detection of infected individuals.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:104 |
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| Enthalten in: |
Diagnostic microbiology and infectious disease - 104(2022), 3 vom: 13. Nov., Seite 115786 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Leventopoulos, Michail [VerfasserIn] |
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| Links: |
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| Themen: |
Antigens, Viral |
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| Anmerkungen: |
Date Completed 11.10.2022 Date Revised 21.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.diagmicrobio.2022.115786 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a The gold standard test available for detecting COVID-19 patients is Real Time RT-PCR. However, this method is expensive, needing special equipment and skilled laboratory staff. Recently, less expensive antigen tests have become available, that could easily and rapidly identify new COVID-19 cases. Our objective was to evaluate the Boson Rapid Antigen Test Card versus the RT-rtPCR, using samples taken both by laymen (self-testing) and professionals. The sensitivity, specificity and accuracy rates were, 98.18%, 100.00%, and 99.28%, respectively. The positive and negative predictive values were 100.00% and 98.82%, respectively. The detection rate for asymptomatic patients was 90.48%, and detection rate for Ct values ≥30 was 91.67%. Our results indicate a high coincidence rate between the Boson and the referencing RT-rtPCR method, meeting the performance standards recommended by the WHO. Therefore, this test could facilitate a fast self-testing screening method, for the detection of infected individuals | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a BOSON | |
| 650 | 4 | |a COVID–19 | |
| 650 | 4 | |a Rapid antigen test | |
| 650 | 4 | |a Real Time RT–PCR | |
| 650 | 4 | |a SARS–CoV–2 | |
| 650 | 4 | |a Self–testing | |
| 650 | 7 | |a Antigens, Viral |2 NLM | |
| 700 | 1 | |a Michou, Vassiliki |e verfasserin |4 aut | |
| 700 | 1 | |a Papadimitropoulos, Miltiadis |e verfasserin |4 aut | |
| 700 | 1 | |a Vourva, Evangelia |e verfasserin |4 aut | |
| 700 | 1 | |a Manias, Nikolaos George |e verfasserin |4 aut | |
| 700 | 1 | |a Kavvadas, Harilaos Panagiotis |e verfasserin |4 aut | |
| 700 | 1 | |a Nikolopoulos, Dimitris |e verfasserin |4 aut | |
| 700 | 1 | |a Tsilivakos, Vassilis |e verfasserin |4 aut | |
| 700 | 1 | |a Georgoulias, Georgios |e verfasserin |4 aut | |
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