Recent Insights on Synthetic Methods and Pharmacological Potential in Relation with Structure of Benzothiazoles
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
Benzothiazole is a bicyclic heterocyclic compound that contains benzene fused with 1, 3- thiazole ring. Several researches established the potential of benzothiazoles as important moiety in various adverse pharmacological conditions. Benzothiazole and its derivatives have been in use and marketed as anti-microbial, anti-inflammatory, anti-diabetic, anti-oxidant, anti-convulsant, antitumor, etc. The variations in pharmacological potentials of benzothiazole and its derivatives have been rational with their chemical structure. Nowadays, hybridization of two or more pharmacophores to synthesize a single molecule with potent pharmacological action is used. This helps to synergize pharmacological properties, make interaction possible with many targets, or minimize the adverse effects associated with them. Several synthetic approaches have been reported for benzothiazole and its derivatives. In this present review article, we focused on recently adopted synthetic approaches for the synthesis of the benzothiazole nucleus and its derivatives. The structure-activity relationship in relation to different pharmacological activities has also been highlighted to provide a good understanding to the researchers for future research on benzothiazoles.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
Medicinal chemistry (Shariqah (United Arab Emirates)) - 19(2023), 4 vom: 14., Seite 325-360 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yadav, Ranjeet Kumar [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 27.03.2023 Date Revised 27.03.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.2174/1573406418666220820110551 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Benzothiazole is a bicyclic heterocyclic compound that contains benzene fused with 1, 3- thiazole ring. Several researches established the potential of benzothiazoles as important moiety in various adverse pharmacological conditions. Benzothiazole and its derivatives have been in use and marketed as anti-microbial, anti-inflammatory, anti-diabetic, anti-oxidant, anti-convulsant, antitumor, etc. The variations in pharmacological potentials of benzothiazole and its derivatives have been rational with their chemical structure. Nowadays, hybridization of two or more pharmacophores to synthesize a single molecule with potent pharmacological action is used. This helps to synergize pharmacological properties, make interaction possible with many targets, or minimize the adverse effects associated with them. Several synthetic approaches have been reported for benzothiazole and its derivatives. In this present review article, we focused on recently adopted synthetic approaches for the synthesis of the benzothiazole nucleus and its derivatives. The structure-activity relationship in relation to different pharmacological activities has also been highlighted to provide a good understanding to the researchers for future research on benzothiazoles | ||
| 650 | 4 | |a Review | |
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| 650 | 4 | |a Benzothiazole | |
| 650 | 4 | |a chemical structure | |
| 650 | 4 | |a pharmacological potential | |
| 650 | 4 | |a structure-activity relationship | |
| 650 | 4 | |a synthesis | |
| 650 | 4 | |a synthetic approach | |
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| 650 | 7 | |a Anti-Inflammatory Agents |2 NLM | |
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| 700 | 1 | |a Salahuddin |e verfasserin |4 aut | |
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| 700 | 1 | |a Abdullah, Mohd Mustaqeem |e verfasserin |4 aut | |
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