Effect of Supplementation of Vitamin D in Patients with Periodontitis Evaluated before and after Nonsurgical Therapy
Copyright © 2022 Shree Mohan Mishra et al..
Background: Vitamin D has anti-inflammatory properties and the potential to increase the generation of antimicrobial peptides like cathelicidin and defensins that may have a good impact on oral health. Higher vitamin D consumption has also been linked to a reduced risk of periodontal disease progression. Hence, the primary objective of this study was to evaluate and compare the clinical and laboratory parameters of oral supplementation of vitamin D as an adjuvant to scaling and root planing and to assess the bone mineral density via qualitative ultrasound bone density scanner in chronic periodontitis patients. Methodology. This study included 40 patients with periodontitis categorized into 2 groups with twenty patients each, Group I comprising scaling and root planing (SRP) alone and Group II comprising SRP along with vitamin D supplementation. Plaque index, gingival index, probing pocket depth, and clinical attachment loss was measured as clinical parameters. Serum vitamin D levels were assessed before and after SRP at both baseline and 6 weeks.
Results: The intergroup comparison of clinical parameters (PI, GI, PPD, and CAL) at 6 weeks for both the groups showed statistical significance. Intragroup comparison of clinical parameters from baseline to 6 weeks showed a statistically significant reduction in both groups. The mean bone mineral density level in both the control and test groups demonstrated a mean T score of -1.3 and -1.21, respectively. The mean vitamin D levels were 27.8460 and 28.1020 for the test and control groups, respectively, which was statistically insignificant (p = 0.705) and those at six-week intervals improved to 31.3650 and 28.0240 which were statistically significant (p ≤ 0.001).
Conclusion: It could be stated that a positive relationship exists between periodontitis and osteopenia which could aggravate periodontal destruction. All periodontitis cases should thus be evaluated for BMD and supplemented with vitamin D3 in an appropriate dosage and time frame to treat both these diseases.
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RetractionIn: Biomed Res Int. 2023 Sep 27;2023:9850874. - PMID 37799169 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2022 |
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| Enthalten in: |
BioMed research international - 2022(2022) vom: 29., Seite 5869676 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mishra, Shree Mohan [VerfasserIn] |
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Date Completed 19.08.2022 Date Revised 06.10.2023 published: Electronic-eCollection RetractionIn: Biomed Res Int. 2023 Sep 27;2023:9850874. - PMID 37799169 Citation Status MEDLINE |
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| doi: |
10.1155/2022/5869676 |
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| 245 | 1 | 0 | |a Effect of Supplementation of Vitamin D in Patients with Periodontitis Evaluated before and after Nonsurgical Therapy |
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| 500 | |a RetractionIn: Biomed Res Int. 2023 Sep 27;2023:9850874. - PMID 37799169 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Shree Mohan Mishra et al. | ||
| 520 | |a Background: Vitamin D has anti-inflammatory properties and the potential to increase the generation of antimicrobial peptides like cathelicidin and defensins that may have a good impact on oral health. Higher vitamin D consumption has also been linked to a reduced risk of periodontal disease progression. Hence, the primary objective of this study was to evaluate and compare the clinical and laboratory parameters of oral supplementation of vitamin D as an adjuvant to scaling and root planing and to assess the bone mineral density via qualitative ultrasound bone density scanner in chronic periodontitis patients. Methodology. This study included 40 patients with periodontitis categorized into 2 groups with twenty patients each, Group I comprising scaling and root planing (SRP) alone and Group II comprising SRP along with vitamin D supplementation. Plaque index, gingival index, probing pocket depth, and clinical attachment loss was measured as clinical parameters. Serum vitamin D levels were assessed before and after SRP at both baseline and 6 weeks | ||
| 520 | |a Results: The intergroup comparison of clinical parameters (PI, GI, PPD, and CAL) at 6 weeks for both the groups showed statistical significance. Intragroup comparison of clinical parameters from baseline to 6 weeks showed a statistically significant reduction in both groups. The mean bone mineral density level in both the control and test groups demonstrated a mean T score of -1.3 and -1.21, respectively. The mean vitamin D levels were 27.8460 and 28.1020 for the test and control groups, respectively, which was statistically insignificant (p = 0.705) and those at six-week intervals improved to 31.3650 and 28.0240 which were statistically significant (p ≤ 0.001) | ||
| 520 | |a Conclusion: It could be stated that a positive relationship exists between periodontitis and osteopenia which could aggravate periodontal destruction. All periodontitis cases should thus be evaluated for BMD and supplemented with vitamin D3 in an appropriate dosage and time frame to treat both these diseases | ||
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| 700 | 1 | |a Rajula, Prem Blaisie |e verfasserin |4 aut | |
| 700 | 1 | |a Gayathri, K |e verfasserin |4 aut | |
| 700 | 1 | |a Alam, Mohammad Khursheed |e verfasserin |4 aut | |
| 700 | 1 | |a Raj, A Thirumal |e verfasserin |4 aut | |
| 700 | 1 | |a Bhandi, Shilpa |e verfasserin |4 aut | |
| 700 | 1 | |a Patil, Shankargouda |e verfasserin |4 aut | |
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