Epidemiological, virological and serological investigation of a SARS-CoV-2 outbreak (Alpha variant) in a primary school : A prospective longitudinal study
OBJECTIVES: To report a prospective epidemiological, virological and serological investigation of a SARS-CoV-2 outbreak in a primary school.
METHODS: As part of a longitudinal, prospective, school-based surveillance study, this investigation involved repeated testing of 73 pupils, 9 teachers, 13 non-teaching staff and 26 household members of participants who tested positive, with rapid antigen tests and/or RT-PCR (Day 0-2 and Day 5-7), serologies on dried capillary blood samples (Day 0-2 and Day 30), contact tracing interviews and SARS-CoV-2 whole genome sequencing.
RESULTS: We identified 20 children (aged 4 to 6 years from 4 school classes), 2 teachers and a total of 4 household members who were infected by the Alpha variant during this outbreak. Infection attack rates were between 11.8 and 62.0% among pupils from the 4 school classes, 22.2% among teachers and 0% among non-teaching staff. Secondary attack rate among household members was 15.4%. Symptoms were reported by 63% of infected children, 100% of teachers and 50% of household members. All analysed sequences but one showed 100% identity. Serological tests detected 8 seroconversions unidentified by SARS-CoV-2 virological tests.
CONCLUSIONS: This study confirmed child-to-child and child-to-adult SARS-CoV-2 transmission and introduction into households. Effective measures to limit transmission in schools have the potential to reduce the overall community circulation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
PloS one - 17(2022), 8 vom: 01., Seite e0272663 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lorthe, Elsa [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 19.08.2022 Date Revised 07.09.2022 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.1371/journal.pone.0272663 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM344955826 |
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| 100 | 1 | |a Lorthe, Elsa |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Epidemiological, virological and serological investigation of a SARS-CoV-2 outbreak (Alpha variant) in a primary school |b A prospective longitudinal study |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Revised 07.09.2022 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: To report a prospective epidemiological, virological and serological investigation of a SARS-CoV-2 outbreak in a primary school | ||
| 520 | |a METHODS: As part of a longitudinal, prospective, school-based surveillance study, this investigation involved repeated testing of 73 pupils, 9 teachers, 13 non-teaching staff and 26 household members of participants who tested positive, with rapid antigen tests and/or RT-PCR (Day 0-2 and Day 5-7), serologies on dried capillary blood samples (Day 0-2 and Day 30), contact tracing interviews and SARS-CoV-2 whole genome sequencing | ||
| 520 | |a RESULTS: We identified 20 children (aged 4 to 6 years from 4 school classes), 2 teachers and a total of 4 household members who were infected by the Alpha variant during this outbreak. Infection attack rates were between 11.8 and 62.0% among pupils from the 4 school classes, 22.2% among teachers and 0% among non-teaching staff. Secondary attack rate among household members was 15.4%. Symptoms were reported by 63% of infected children, 100% of teachers and 50% of household members. All analysed sequences but one showed 100% identity. Serological tests detected 8 seroconversions unidentified by SARS-CoV-2 virological tests | ||
| 520 | |a CONCLUSIONS: This study confirmed child-to-child and child-to-adult SARS-CoV-2 transmission and introduction into households. Effective measures to limit transmission in schools have the potential to reduce the overall community circulation | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Bellon, Mathilde |e verfasserin |4 aut | |
| 700 | 1 | |a Michielin, Grégoire |e verfasserin |4 aut | |
| 700 | 1 | |a Berthelot, Julie |e verfasserin |4 aut | |
| 700 | 1 | |a Zaballa, María-Eugenia |e verfasserin |4 aut | |
| 700 | 1 | |a Pennacchio, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Bekliz, Meriem |e verfasserin |4 aut | |
| 700 | 1 | |a Laubscher, Florian |e verfasserin |4 aut | |
| 700 | 1 | |a Arefi, Fatemeh |e verfasserin |4 aut | |
| 700 | 1 | |a Perez-Saez, Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Azman, Andrew S |e verfasserin |4 aut | |
| 700 | 1 | |a L'Huillier, Arnaud G |e verfasserin |4 aut | |
| 700 | 1 | |a Posfay-Barbe, Klara M |e verfasserin |4 aut | |
| 700 | 1 | |a Kaiser, Laurent |e verfasserin |4 aut | |
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