Bisabolane-type sesquiterpenoids with potential anti-inflammatory and anti-HIV activities from the stems and leaves of Morinda citrifolia
The phytochemical study on the stems and leaves of Morinda citrifolia L. resulted in the isolation of a new naturally occurring bisabolane-type sesquiterpenoid, morincitrinoid A (1), together with five known analogues (2-6). The chemical structure of 1 was elucidated by comprehensive spectral analyses. The known compounds 2-6 were identified by comparing their spectral data with those reported in the literature, which were isolated from M. citrifolia for the first time. In addition, the anti-inflammatory and anti-HIV activities of compounds 1-6 were evaluated in vitro. Compounds 1-6 displayed significant inhibitory activities on NO (nitric oxide) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells with IC50 values ranging from 0.98 ± 0.07 to 6.32 ± 0.11 μM, which was comparable to hydrocortisone. Meanwhile, compounds 1-6 showed remarkable anti-HIV-1 reverse transcriptase (RT) effects with the EC50 values ranging from 0.16 to 6.29 μM.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
Natural product research - 37(2023), 12 vom: 01. Juni, Seite 1961-1968 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhao, Ying-Ying [VerfasserIn] |
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| Links: |
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| Themen: |
31C4KY9ESH |
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| Anmerkungen: |
Date Completed 30.05.2023 Date Revised 30.05.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/14786419.2022.2112577 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM344944158 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The phytochemical study on the stems and leaves of Morinda citrifolia L. resulted in the isolation of a new naturally occurring bisabolane-type sesquiterpenoid, morincitrinoid A (1), together with five known analogues (2-6). The chemical structure of 1 was elucidated by comprehensive spectral analyses. The known compounds 2-6 were identified by comparing their spectral data with those reported in the literature, which were isolated from M. citrifolia for the first time. In addition, the anti-inflammatory and anti-HIV activities of compounds 1-6 were evaluated in vitro. Compounds 1-6 displayed significant inhibitory activities on NO (nitric oxide) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells with IC50 values ranging from 0.98 ± 0.07 to 6.32 ± 0.11 μM, which was comparable to hydrocortisone. Meanwhile, compounds 1-6 showed remarkable anti-HIV-1 reverse transcriptase (RT) effects with the EC50 values ranging from 0.16 to 6.29 μM | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Morinda citrifolia | |
| 650 | 4 | |a anti-HIV effects | |
| 650 | 4 | |a anti-inflammatory activities | |
| 650 | 4 | |a morincitrinoid A | |
| 650 | 4 | |a sesquiterpenoids | |
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| 650 | 7 | |a Monocyclic Sesquiterpenes |2 NLM | |
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| 700 | 1 | |a Yu, Xiao-Mei |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Qin-Ting |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Li-Wen |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Yu-Shu |e verfasserin |4 aut | |
| 700 | 1 | |a Fu, Yan-Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Guang-Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yan-Ping |e verfasserin |4 aut | |
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