Blood Pressure and Later-Life Cognition in Hispanic and White Adults (BP-COG) : A Pooled Cohort Analysis of ARIC, CARDIA, CHS, FOS, MESA, and NOMAS
BACKGROUND: Ethnic differences in cognitive decline have been reported. Whether they can be explained by differences in systolic blood pressure (SBP) is uncertain.
OBJECTIVE: Determine whether cumulative mean SBP levels explain differences in cognitive decline between Hispanic and White individuals.
METHODS: Pooled cohort study of individual participant data from six cohorts (1971-2017). The present study reports results on SBP and cognition among Hispanic and White individuals. Outcomes were changes in global cognition (GC) (primary), executive function (EF) (secondary), and memory standardized as t-scores (mean [SD], 50 [10]); a 1-point difference represents a 0.1 SD difference in cognition. Median follow-up was 7.7 (Q1-Q3, 5.2-20.1) years.
RESULTS: We included 24,570 participants free of stroke and dementia: 2,475 Hispanic individuals (median age, cumulative mean SBP at first cognitive assessment, 67 years, 132.5 mmHg; 40.8% men) and 22,095 White individuals (60 years,134 mmHg; 47.3% men). Hispanic individuals had slower declines in GC, EF, and memory than White individuals when all six cohorts were examined. Two cohorts recruited Hispanic individuals by design. In a sensitivity analysis, Hispanic individuals in these cohorts had faster decline in GC, similar decline in EF, and slower decline in memory than White individuals. Higher time-varying cumulative mean SBP was associated with faster declines in GC, EF, and memory in all analyses. After adjusting for time-varying cumulative mean SBP, differences in cognitive slopes between Hispanic and White individuals did not change.
CONCLUSION: We found no evidence that cumulative mean SBP differences explained differences in cognitive decline between Hispanic and White individuals.
| Errataetall: |
ErratumIn: J Alzheimers Dis. 2023;92(2):723. - PMID 36911952 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:89 |
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| Enthalten in: |
Journal of Alzheimer's disease : JAD - 89(2022), 3 vom: 23., Seite 1103-1117 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Levine, Deborah A [VerfasserIn] |
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| Links: |
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| Themen: |
Blood pressure |
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| Anmerkungen: |
Date Completed 04.10.2022 Date Revised 04.04.2024 published: Print ErratumIn: J Alzheimers Dis. 2023;92(2):723. - PMID 36911952 Citation Status MEDLINE |
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| doi: |
10.3233/JAD-220366 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM344829294 |
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| 100 | 1 | |a Levine, Deborah A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Blood Pressure and Later-Life Cognition in Hispanic and White Adults (BP-COG) |b A Pooled Cohort Analysis of ARIC, CARDIA, CHS, FOS, MESA, and NOMAS |
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| 500 | |a Date Completed 04.10.2022 | ||
| 500 | |a Date Revised 04.04.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a ErratumIn: J Alzheimers Dis. 2023;92(2):723. - PMID 36911952 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Ethnic differences in cognitive decline have been reported. Whether they can be explained by differences in systolic blood pressure (SBP) is uncertain | ||
| 520 | |a OBJECTIVE: Determine whether cumulative mean SBP levels explain differences in cognitive decline between Hispanic and White individuals | ||
| 520 | |a METHODS: Pooled cohort study of individual participant data from six cohorts (1971-2017). The present study reports results on SBP and cognition among Hispanic and White individuals. Outcomes were changes in global cognition (GC) (primary), executive function (EF) (secondary), and memory standardized as t-scores (mean [SD], 50 [10]); a 1-point difference represents a 0.1 SD difference in cognition. Median follow-up was 7.7 (Q1-Q3, 5.2-20.1) years | ||
| 520 | |a RESULTS: We included 24,570 participants free of stroke and dementia: 2,475 Hispanic individuals (median age, cumulative mean SBP at first cognitive assessment, 67 years, 132.5 mmHg; 40.8% men) and 22,095 White individuals (60 years,134 mmHg; 47.3% men). Hispanic individuals had slower declines in GC, EF, and memory than White individuals when all six cohorts were examined. Two cohorts recruited Hispanic individuals by design. In a sensitivity analysis, Hispanic individuals in these cohorts had faster decline in GC, similar decline in EF, and slower decline in memory than White individuals. Higher time-varying cumulative mean SBP was associated with faster declines in GC, EF, and memory in all analyses. After adjusting for time-varying cumulative mean SBP, differences in cognitive slopes between Hispanic and White individuals did not change | ||
| 520 | |a CONCLUSION: We found no evidence that cumulative mean SBP differences explained differences in cognitive decline between Hispanic and White individuals | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Intramural | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Blood pressure | |
| 650 | 4 | |a Hispanic Americans | |
| 650 | 4 | |a cognition | |
| 650 | 4 | |a dementia | |
| 650 | 4 | |a ethnic groups | |
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| 700 | 1 | |a Tilton, Nicholas |e verfasserin |4 aut | |
| 700 | 1 | |a Whitney, Rachael |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Dehua |e verfasserin |4 aut | |
| 700 | 1 | |a Giordani, Bruno J |e verfasserin |4 aut | |
| 700 | 1 | |a Sussman, Jeremy B |e verfasserin |4 aut | |
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| 700 | 1 | |a Elkind, Mitchell S V |e verfasserin |4 aut | |
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| 700 | 1 | |a Galecki, Andrzej T |e verfasserin |4 aut | |
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