Adoptive B cell therapy for chronic viral infection
Copyright © 2022 Chung, Dangi, Palacio, Sanchez and Penaloza-MacMaster..
T cell-based therapies have been widely explored for the treatment of cancer and chronic infection, but B cell-based therapies have remained largely unexplored. To study the effect of B cell therapy, we adoptively transferred virus-specific B cells into mice that were chronically infected with lymphocytic choriomeningitis virus (LCMV). Adoptive transfer of virus-specific B cells resulted in increase in antibody titers and reduction of viral loads. Importantly, the efficacy of B cell therapy was partly dependent on antibody effector functions, and was improved by co-transferring virus-specific CD4 T cells. These findings provide a proof-of-concept that adoptive B cell therapy can be effective for the treatment of chronic infections, but provision of virus-specific CD4 T cells may be critical for optimal virus neutralization.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Frontiers in immunology - 13(2022) vom: 01., Seite 908707 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chung, Young Rock [VerfasserIn] |
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| Links: |
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| Themen: |
Adoptive cell therapy |
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| Anmerkungen: |
Date Completed 15.08.2022 Date Revised 01.07.2023 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.3389/fimmu.2022.908707 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM344774082 |
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| 520 | |a Copyright © 2022 Chung, Dangi, Palacio, Sanchez and Penaloza-MacMaster. | ||
| 520 | |a T cell-based therapies have been widely explored for the treatment of cancer and chronic infection, but B cell-based therapies have remained largely unexplored. To study the effect of B cell therapy, we adoptively transferred virus-specific B cells into mice that were chronically infected with lymphocytic choriomeningitis virus (LCMV). Adoptive transfer of virus-specific B cells resulted in increase in antibody titers and reduction of viral loads. Importantly, the efficacy of B cell therapy was partly dependent on antibody effector functions, and was improved by co-transferring virus-specific CD4 T cells. These findings provide a proof-of-concept that adoptive B cell therapy can be effective for the treatment of chronic infections, but provision of virus-specific CD4 T cells may be critical for optimal virus neutralization | ||
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| 700 | 1 | |a Palacio, Nicole |e verfasserin |4 aut | |
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| 700 | 1 | |a Penaloza-MacMaster, Pablo |e verfasserin |4 aut | |
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