Association between dietary intake of n-3 polyunsaturated fatty acids and risk of colorectal cancer in the Japanese population : The Japan Collaborative Cohort Study
© 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd..
BACKGROUND: Epidemiological studies of the dietary intake of specific n-3 polyunsaturated fatty acids (PUFA) and anatomical subsite-specific colorectal cancer (CRC) are limited. We examined the prospective associations of total n-3 PUFA, marine-derived n-3 PUFA [combined eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA)], and alpha-linolenic acid (ALA) as plant-derived n-3 PUFA with the risk of CRC by subsite in the Japan Collaborative Cohort Study.
METHODS: The participants completed a self-administered food frequency questionnaire and had no prior history of CRC. Cox proportional hazards model was used to determine the associations between n-3 PUFAs intake and CRC risk overall and by anatomical subsite.
RESULTS: During the median 13.8-year follow-up period, 699 of the 42,536 participants aged 40-79 years developed incident CRC. An inverse association was found between dietary ALA intake and the risk of distal colon cancer; the multivariable hazard ratios and 95% confidence intervals for the highest quartiles (Q4) were 0.41 (0.21-0.81; p trend = 0.01) compared with the lowest quartiles (Q1). Marine n-3 PUFA intake was not associated with CRC risk in the overall or anatomical subsite-specific analyses.
CONCLUSION: Our findings suggest that higher ALA intake may be beneficial for lowering the risk of distal colon cancer.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Cancer medicine - 12(2023), 4 vom: 24. Feb., Seite 4690-4700 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kato, Ayako [VerfasserIn] |
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| Links: |
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| Themen: |
Alpha-linolenic acid |
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| Anmerkungen: |
Date Completed 02.03.2023 Date Revised 17.03.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/cam4.5098 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM34465866X |
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| 500 | |a Date Revised 17.03.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. | ||
| 520 | |a BACKGROUND: Epidemiological studies of the dietary intake of specific n-3 polyunsaturated fatty acids (PUFA) and anatomical subsite-specific colorectal cancer (CRC) are limited. We examined the prospective associations of total n-3 PUFA, marine-derived n-3 PUFA [combined eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA)], and alpha-linolenic acid (ALA) as plant-derived n-3 PUFA with the risk of CRC by subsite in the Japan Collaborative Cohort Study | ||
| 520 | |a METHODS: The participants completed a self-administered food frequency questionnaire and had no prior history of CRC. Cox proportional hazards model was used to determine the associations between n-3 PUFAs intake and CRC risk overall and by anatomical subsite | ||
| 520 | |a RESULTS: During the median 13.8-year follow-up period, 699 of the 42,536 participants aged 40-79 years developed incident CRC. An inverse association was found between dietary ALA intake and the risk of distal colon cancer; the multivariable hazard ratios and 95% confidence intervals for the highest quartiles (Q4) were 0.41 (0.21-0.81; p trend = 0.01) compared with the lowest quartiles (Q1). Marine n-3 PUFA intake was not associated with CRC risk in the overall or anatomical subsite-specific analyses | ||
| 520 | |a CONCLUSION: Our findings suggest that higher ALA intake may be beneficial for lowering the risk of distal colon cancer | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Japan | |
| 650 | 4 | |a alpha-linolenic acid | |
| 650 | 4 | |a colorectal cancer | |
| 650 | 4 | |a n-3 polyunsaturated fatty acid | |
| 650 | 4 | |a prospective study | |
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| 700 | 1 | |a Iso, Hiroyasu |e verfasserin |4 aut | |
| 700 | 1 | |a Tamakoshi, Akiko |e verfasserin |4 aut | |
| 700 | 0 | |a JACC Study Group |e verfasserin |4 aut | |
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