Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19
Whereas pathogen-specific T and B cells are a primary focus of interest during infectious disease, we have used COVID-19 to ask whether their emergence comes at a cost of broader B cell and T cell repertoire disruption. We applied a genomic DNA-based approach to concurrently study the immunoglobulin-heavy (IGH) and T cell receptor (TCR) β and δ chain loci of 95 individuals. Our approach detected anticipated repertoire focusing for the IGH repertoire, including expansions of clusters of related sequences temporally aligned with SARS-CoV-2-specific seroconversion, and enrichment of some shared SARS-CoV-2-associated sequences. No significant age-related or disease severity-related deficiencies were noted for the IGH repertoire. By contrast, whereas focusing occurred at the TCRβ and TCRδ loci, including some TCRβ sequence-sharing, disruptive repertoire narrowing was almost entirely limited to many patients aged older than 50 y. By temporarily reducing T cell diversity and by risking expansions of nonbeneficial T cells, these traits may constitute an age-related risk factor for COVID-19, including a vulnerability to new variants for which T cells may provide key protection.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:119 |
|---|---|
| Enthalten in: |
Proceedings of the National Academy of Sciences of the United States of America - 119(2022), 34 vom: 23. Aug., Seite e2201541119 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Joseph, Magdalene [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 11.08.2022 Date Revised 22.03.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1073/pnas.2201541119 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM344633799 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM344633799 | ||
| 003 | DE-627 | ||
| 005 | 20231226023228.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1073/pnas.2201541119 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1148.xml |
| 035 | |a (DE-627)NLM344633799 | ||
| 035 | |a (NLM)35943978 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Joseph, Magdalene |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19 |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 11.08.2022 | ||
| 500 | |a Date Revised 22.03.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Whereas pathogen-specific T and B cells are a primary focus of interest during infectious disease, we have used COVID-19 to ask whether their emergence comes at a cost of broader B cell and T cell repertoire disruption. We applied a genomic DNA-based approach to concurrently study the immunoglobulin-heavy (IGH) and T cell receptor (TCR) β and δ chain loci of 95 individuals. Our approach detected anticipated repertoire focusing for the IGH repertoire, including expansions of clusters of related sequences temporally aligned with SARS-CoV-2-specific seroconversion, and enrichment of some shared SARS-CoV-2-associated sequences. No significant age-related or disease severity-related deficiencies were noted for the IGH repertoire. By contrast, whereas focusing occurred at the TCRβ and TCRδ loci, including some TCRβ sequence-sharing, disruptive repertoire narrowing was almost entirely limited to many patients aged older than 50 y. By temporarily reducing T cell diversity and by risking expansions of nonbeneficial T cells, these traits may constitute an age-related risk factor for COVID-19, including a vulnerability to new variants for which T cells may provide key protection | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a adaptive immune responses | |
| 650 | 4 | |a antigen-receptor repertoires | |
| 650 | 4 | |a immunoPETE | |
| 650 | 4 | |a next-generation sequencing | |
| 650 | 7 | |a Immunoglobulin Heavy Chains |2 NLM | |
| 650 | 7 | |a Receptors, Antigen, T-Cell |2 NLM | |
| 650 | 7 | |a Receptors, Antigen, T-Cell, alpha-beta |2 NLM | |
| 700 | 1 | |a Wu, Yin |e verfasserin |4 aut | |
| 700 | 1 | |a Dannebaum, Richard |e verfasserin |4 aut | |
| 700 | 1 | |a Rubelt, Florian |e verfasserin |4 aut | |
| 700 | 1 | |a Zlatareva, Iva |e verfasserin |4 aut | |
| 700 | 1 | |a Lorenc, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Du, Zhipei Gracie |e verfasserin |4 aut | |
| 700 | 1 | |a Davies, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Kyle-Cezar, Fernanda |e verfasserin |4 aut | |
| 700 | 1 | |a Das, Abhishek |e verfasserin |4 aut | |
| 700 | 1 | |a Gee, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Seow, Jeffrey |e verfasserin |4 aut | |
| 700 | 1 | |a Graham, Carl |e verfasserin |4 aut | |
| 700 | 1 | |a Telman, Dilduz |e verfasserin |4 aut | |
| 700 | 1 | |a Bermejo, Clara |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Hai |e verfasserin |4 aut | |
| 700 | 1 | |a Asgharian, Hosseinali |e verfasserin |4 aut | |
| 700 | 1 | |a Laing, Adam G |e verfasserin |4 aut | |
| 700 | 1 | |a Del Molino Del Barrio, Irene |e verfasserin |4 aut | |
| 700 | 1 | |a Monin, Leticia |e verfasserin |4 aut | |
| 700 | 1 | |a Muñoz-Ruiz, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a McKenzie, Duncan R |e verfasserin |4 aut | |
| 700 | 1 | |a Hayday, Thomas S |e verfasserin |4 aut | |
| 700 | 1 | |a Francos-Quijorna, Isaac |e verfasserin |4 aut | |
| 700 | 1 | |a Kamdar, Shraddha |e verfasserin |4 aut | |
| 700 | 1 | |a Davis, Richard |e verfasserin |4 aut | |
| 700 | 1 | |a Sofra, Vasiliki |e verfasserin |4 aut | |
| 700 | 1 | |a Cano, Florencia |e verfasserin |4 aut | |
| 700 | 1 | |a Theodoridis, Efstathios |e verfasserin |4 aut | |
| 700 | 1 | |a Martinez, Lauren |e verfasserin |4 aut | |
| 700 | 1 | |a Merrick, Blair |e verfasserin |4 aut | |
| 700 | 1 | |a Bisnauthsing, Karen |e verfasserin |4 aut | |
| 700 | 1 | |a Brooks, Kate |e verfasserin |4 aut | |
| 700 | 1 | |a Edgeworth, Jonathan |e verfasserin |4 aut | |
| 700 | 1 | |a Cason, John |e verfasserin |4 aut | |
| 700 | 1 | |a Mant, Christine |e verfasserin |4 aut | |
| 700 | 1 | |a Doores, Katie J |e verfasserin |4 aut | |
| 700 | 1 | |a Vantourout, Pierre |e verfasserin |4 aut | |
| 700 | 1 | |a Luong, Khai |e verfasserin |4 aut | |
| 700 | 1 | |a Berka, Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Hayday, Adrian C |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Proceedings of the National Academy of Sciences of the United States of America |d 1915 |g 119(2022), 34 vom: 23. Aug., Seite e2201541119 |w (DE-627)NLM000008982 |x 1091-6490 |7 nnns |
| 773 | 1 | 8 | |g volume:119 |g year:2022 |g number:34 |g day:23 |g month:08 |g pages:e2201541119 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1073/pnas.2201541119 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 119 |j 2022 |e 34 |b 23 |c 08 |h e2201541119 | ||