Hemodynamic reserve predicts early right heart failure after LVAD implantation
Copyright © 2022 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved..
BACKGROUND: Early right heart failure (RHF) remains a major source of morbidity and mortality after left ventricular assist device (LVAD) implantation, yet efforts to predict early RHF have proven only modestly successful. Pharmacologic unloading of the left ventricle may be a risk stratification approach allowing for assessment of right ventricular and hemodynamic reserve.
METHODS: We performed a multicenter, retrospective analysis of patients who had undergone continuous-flow LVAD implantation from October 2011 to April 2020. Only those who underwent vasodilator testing with nitroprusside during their preimplant right heart catheterization were included (n = 70). Multivariable logistic regression was used to determine independent predictors of early RHF as defined by Mechanical Circulatory Support-Academic Research Consortium.
RESULTS: Twenty-seven patients experienced post-LVAD early RHF (39%). Baseline clinical characteristics were similar between patients with and without RHF. Patients without RHF, however, achieved higher peak stroke volume index (SVI) (30.1 ± 8.8 vs 21.7 ± 7.4 mL/m2; p < 0.001; AUC: 0.78; optimal cut-point: 22.1 mL/m2) during nitroprusside administration. Multivariable analysis revealed that peak SVI was significantly associated with early RHF, demonstrating a 16% increase in risk of early RHF per 1 ml/m2 decrease in SVI. A follow up cohort of 10 consecutive patients from July 2020 to October 2021 resulted in all patients being categorized appropriately in regards to early RHF versus no RHF according to peak SVI.
CONCLUSION: Peak SVI with nitroprusside administration was independently associated with post-LVAD early RHF while resting hemodynamics were not. Vasodilator testing may prove to be a strong risk stratification tool when assessing LVAD candidacy though additional prospective validation is needed.
| Errataetall: |
CommentIn: J Heart Lung Transplant. 2022 Dec;41(12):1727-1728. - PMID 36153277 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
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| Enthalten in: |
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 41(2022), 12 vom: 30. Dez., Seite 1716-1726 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Read, Jacob M [VerfasserIn] |
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| Links: |
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| Themen: |
169D1260KM |
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| Anmerkungen: |
Date Completed 29.11.2022 Date Revised 10.02.2024 published: Print-Electronic CommentIn: J Heart Lung Transplant. 2022 Dec;41(12):1727-1728. - PMID 36153277 Citation Status MEDLINE |
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| doi: |
10.1016/j.healun.2022.07.003 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM344540588 |
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| 245 | 1 | 0 | |a Hemodynamic reserve predicts early right heart failure after LVAD implantation |
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| 500 | |a Date Revised 10.02.2024 | ||
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| 500 | |a CommentIn: J Heart Lung Transplant. 2022 Dec;41(12):1727-1728. - PMID 36153277 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Early right heart failure (RHF) remains a major source of morbidity and mortality after left ventricular assist device (LVAD) implantation, yet efforts to predict early RHF have proven only modestly successful. Pharmacologic unloading of the left ventricle may be a risk stratification approach allowing for assessment of right ventricular and hemodynamic reserve | ||
| 520 | |a METHODS: We performed a multicenter, retrospective analysis of patients who had undergone continuous-flow LVAD implantation from October 2011 to April 2020. Only those who underwent vasodilator testing with nitroprusside during their preimplant right heart catheterization were included (n = 70). Multivariable logistic regression was used to determine independent predictors of early RHF as defined by Mechanical Circulatory Support-Academic Research Consortium | ||
| 520 | |a RESULTS: Twenty-seven patients experienced post-LVAD early RHF (39%). Baseline clinical characteristics were similar between patients with and without RHF. Patients without RHF, however, achieved higher peak stroke volume index (SVI) (30.1 ± 8.8 vs 21.7 ± 7.4 mL/m2; p < 0.001; AUC: 0.78; optimal cut-point: 22.1 mL/m2) during nitroprusside administration. Multivariable analysis revealed that peak SVI was significantly associated with early RHF, demonstrating a 16% increase in risk of early RHF per 1 ml/m2 decrease in SVI. A follow up cohort of 10 consecutive patients from July 2020 to October 2021 resulted in all patients being categorized appropriately in regards to early RHF versus no RHF according to peak SVI | ||
| 520 | |a CONCLUSION: Peak SVI with nitroprusside administration was independently associated with post-LVAD early RHF while resting hemodynamics were not. Vasodilator testing may prove to be a strong risk stratification tool when assessing LVAD candidacy though additional prospective validation is needed | ||
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a hemodynamics | |
| 650 | 4 | |a left ventricular assist device | |
| 650 | 4 | |a pulmonary hypertension | |
| 650 | 4 | |a stroke volume index | |
| 650 | 4 | |a ventricular reserve | |
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| 650 | 7 | |a Vasodilator Agents |2 NLM | |
| 700 | 1 | |a Azih, Nnamdi I |e verfasserin |4 aut | |
| 700 | 1 | |a Peters, Carli J |e verfasserin |4 aut | |
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| 700 | 1 | |a Vishram-Nielsen, Julie K |e verfasserin |4 aut | |
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