Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection
© 2022. The Author(s)..
SARS-CoV-2 infection can cause an inflammatory syndrome (COVID-19) leading, in many cases, to bilateral pneumonia, severe dyspnea, and in ~5% of these, death. DNA methylation is known to play an important role in the regulation of the immune processes behind COVID-19 progression, however it has not been studied in depth. In this study, we aim to evaluate the implication of DNA methylation in COVID-19 progression by means of a genome-wide DNA methylation analysis combined with DNA genotyping. The results reveal the existence of epigenomic regulation of functional pathways associated with COVID-19 progression and mediated by genetic loci. We find an environmental trait-related signature that discriminates mild from severe cases and regulates, among other cytokines, IL-6 expression via the transcription factor CEBP. The analyses suggest that an interaction between environmental contribution, genetics, and epigenetics might be playing a role in triggering the cytokine storm described in the most severe cases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Nature communications - 13(2022), 1 vom: 06. Aug., Seite 4597 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Barturen, Guillermo [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 09.08.2022 Date Revised 28.03.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41467-022-32357-2 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM344529533 |
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| 520 | |a © 2022. The Author(s). | ||
| 520 | |a SARS-CoV-2 infection can cause an inflammatory syndrome (COVID-19) leading, in many cases, to bilateral pneumonia, severe dyspnea, and in ~5% of these, death. DNA methylation is known to play an important role in the regulation of the immune processes behind COVID-19 progression, however it has not been studied in depth. In this study, we aim to evaluate the implication of DNA methylation in COVID-19 progression by means of a genome-wide DNA methylation analysis combined with DNA genotyping. The results reveal the existence of epigenomic regulation of functional pathways associated with COVID-19 progression and mediated by genetic loci. We find an environmental trait-related signature that discriminates mild from severe cases and regulates, among other cytokines, IL-6 expression via the transcription factor CEBP. The analyses suggest that an interaction between environmental contribution, genetics, and epigenetics might be playing a role in triggering the cytokine storm described in the most severe cases | ||
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| 700 | 1 | |a Carnero-Montoro, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez-Bueno, Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Rojo-Rello, Silvia |e verfasserin |4 aut | |
| 700 | 1 | |a Sobrino, Beatriz |e verfasserin |4 aut | |
| 700 | 1 | |a Porras-Perales, Óscar |e verfasserin |4 aut | |
| 700 | 1 | |a Alcántara-Domínguez, Clara |e verfasserin |4 aut | |
| 700 | 1 | |a Bernardo, David |e verfasserin |4 aut | |
| 700 | 1 | |a Alarcón-Riquelme, Marta E |e verfasserin |4 aut | |
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