Maternal soybean diet on prevention of obesity-related breast cancer through early-life gut microbiome and epigenetic regulation
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved..
Overnutrition-induced obesity and metabolic dysregulation are considered major risk factors contributing to breast cancer. The origin of both obesity and breast cancer can retrospect to early development in human lifespan. Genistein (GE), a natural isoflavone enriched in soybean products, has been proposed to associate with a lower risk of breast cancer and various metabolic disorders. Our study aimed to determine the effects of maternal exposure to soybean dietary GE on prevention of overnutrition-induced breast cancer later in life and explore potential mechanisms in different mouse models. Our results showed that maternal dietary GE treatment improved offspring metabolic functions by significantly attenuating high-fat diet-induced body fat accumulation, lipid panel abnormalities and glucose intolerance in mice offspring. Importantly, maternal dietary GE exposure effectively delayed high-fat diet-simulated mammary tumor development in female offspring. Mechanistically, we found that maternal dietary GE may exert its chemopreventive effects through affecting essential regulatory gene expression in control of metabolism, inflammation and tumor development via, at least in part, regulation of offspring gut microbiome, bacterial metabolites and epigenetic profiles. Altogether, our findings indicate that maternal GE consumption is an effective intervention approach leading to early-life prevention of obesity-related metabolic disorders and breast cancer later in life through dynamically influencing the interplay between early-life gut microbiota, key microbial metabolite profiles and offspring epigenome.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:110 |
|---|---|
| Enthalten in: |
The Journal of nutritional biochemistry - 110(2022) vom: 01. Dez., Seite 109119 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Chen, Min [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 01.11.2022 Date Revised 13.12.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.jnutbio.2022.109119 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM344524906 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM344524906 | ||
| 003 | DE-627 | ||
| 005 | 20231227130857.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jnutbio.2022.109119 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1225.xml |
| 035 | |a (DE-627)NLM344524906 | ||
| 035 | |a (NLM)35933021 | ||
| 035 | |a (PII)S0955-2863(22)00187-5 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Chen, Min |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Maternal soybean diet on prevention of obesity-related breast cancer through early-life gut microbiome and epigenetic regulation |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 01.11.2022 | ||
| 500 | |a Date Revised 13.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Overnutrition-induced obesity and metabolic dysregulation are considered major risk factors contributing to breast cancer. The origin of both obesity and breast cancer can retrospect to early development in human lifespan. Genistein (GE), a natural isoflavone enriched in soybean products, has been proposed to associate with a lower risk of breast cancer and various metabolic disorders. Our study aimed to determine the effects of maternal exposure to soybean dietary GE on prevention of overnutrition-induced breast cancer later in life and explore potential mechanisms in different mouse models. Our results showed that maternal dietary GE treatment improved offspring metabolic functions by significantly attenuating high-fat diet-induced body fat accumulation, lipid panel abnormalities and glucose intolerance in mice offspring. Importantly, maternal dietary GE exposure effectively delayed high-fat diet-simulated mammary tumor development in female offspring. Mechanistically, we found that maternal dietary GE may exert its chemopreventive effects through affecting essential regulatory gene expression in control of metabolism, inflammation and tumor development via, at least in part, regulation of offspring gut microbiome, bacterial metabolites and epigenetic profiles. Altogether, our findings indicate that maternal GE consumption is an effective intervention approach leading to early-life prevention of obesity-related metabolic disorders and breast cancer later in life through dynamically influencing the interplay between early-life gut microbiota, key microbial metabolite profiles and offspring epigenome | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 4 | |a Breast cancer | |
| 650 | 4 | |a Epigenetics | |
| 650 | 4 | |a Gut microbiome | |
| 650 | 4 | |a Maternal prevention | |
| 650 | 4 | |a Obesity | |
| 650 | 4 | |a Soybean genistein | |
| 650 | 7 | |a Genistein |2 NLM | |
| 650 | 7 | |a DH2M523P0H |2 NLM | |
| 700 | 1 | |a Li, Shizhao |e verfasserin |4 aut | |
| 700 | 1 | |a Arora, Itika |e verfasserin |4 aut | |
| 700 | 1 | |a Yi, Nengjun |e verfasserin |4 aut | |
| 700 | 1 | |a Sharma, Manvi |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Zhenhai |e verfasserin |4 aut | |
| 700 | 1 | |a Tollefsbol, Trygve O |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yuanyuan |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The Journal of nutritional biochemistry |d 1990 |g 110(2022) vom: 01. Dez., Seite 109119 |w (DE-627)NLM089754956 |x 1873-4847 |7 nnns |
| 773 | 1 | 8 | |g volume:110 |g year:2022 |g day:01 |g month:12 |g pages:109119 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jnutbio.2022.109119 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 110 |j 2022 |b 01 |c 12 |h 109119 | ||