Impact of different COVID-19 waves on kidney replacement therapy epidemiology and mortality : REMER 2020
© The Author(s) 2022. Published by Oxford University Press on behalf of the ERA..
BACKGROUND: Kidney replacement therapy (KRT) confers the highest risk of death from coronavirus disease 2019 (COVID-19). However, most data refer to the early pandemic waves. Whole-year analysis compared with prior secular trends are scarce.
METHODS: We present the 2020 REMER Madrid KRT registry, corresponding to the Spanish Region hardest hit by COVID-19.
RESULTS: In 2020, KRT incidence decreased 12% versus 2019, while KRT prevalence decreased by 1.75% for the first time since records began and the number of kidney transplants (KTs) decreased by 16%. Mortality on KRT was 10.2% (34% higher than the mean for 2008-2019). The 2019-2020 increase in mortality was larger for KTs (+68%) than for haemodialysis (+24%) or peritoneal dialysis (+38%). The most common cause of death was infection [n = 419 (48% of deaths)], followed by cardiovascular [n = 200 (23%)]. Deaths from infection increased by 167% year over year and accounted for 95% of excess deaths in 2020 over 2019. COVID-19 was the most common cause of death (68% of infection deaths, 33% of total deaths). The bulk of COVID-19 deaths [209/285 (73%)] occurred during the first COVID-19 wave, which roughly accounted for the increased mortality in 2020. Being a KT recipient was an independent risk factor for COVID-19 death.
CONCLUSIONS: COVID-19 negatively impacted the incidence and prevalence of KRT, but the increase in KRT deaths was localized to the first wave of the pandemic. The increased annual mortality argues against COVID-19 accelerating the death of patients with short life expectancy and the temporal pattern of COVID-19 mortality suggests that appropriate healthcare may improve outcomes.
| Errataetall: |
ErratumIn: Nephrol Dial Transplant. 2023 Nov 30;38(12):2859. - PMID 37706325 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 37(2022), 11 vom: 19. Okt., Seite 2253-2263 |
| Sprache: |
Englisch |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 24.10.2022 Date Revised 14.09.2023 published: Print ErratumIn: Nephrol Dial Transplant. 2023 Nov 30;38(12):2859. - PMID 37706325 Citation Status MEDLINE |
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| doi: |
10.1093/ndt/gfac234 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM344473287 |
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| 041 | |a eng | ||
| 100 | 1 | |a Carriazo, Sol |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Impact of different COVID-19 waves on kidney replacement therapy epidemiology and mortality |b REMER 2020 |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 24.10.2022 | ||
| 500 | |a Date Revised 14.09.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a ErratumIn: Nephrol Dial Transplant. 2023 Nov 30;38(12):2859. - PMID 37706325 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2022. Published by Oxford University Press on behalf of the ERA. | ||
| 520 | |a BACKGROUND: Kidney replacement therapy (KRT) confers the highest risk of death from coronavirus disease 2019 (COVID-19). However, most data refer to the early pandemic waves. Whole-year analysis compared with prior secular trends are scarce | ||
| 520 | |a METHODS: We present the 2020 REMER Madrid KRT registry, corresponding to the Spanish Region hardest hit by COVID-19 | ||
| 520 | |a RESULTS: In 2020, KRT incidence decreased 12% versus 2019, while KRT prevalence decreased by 1.75% for the first time since records began and the number of kidney transplants (KTs) decreased by 16%. Mortality on KRT was 10.2% (34% higher than the mean for 2008-2019). The 2019-2020 increase in mortality was larger for KTs (+68%) than for haemodialysis (+24%) or peritoneal dialysis (+38%). The most common cause of death was infection [n = 419 (48% of deaths)], followed by cardiovascular [n = 200 (23%)]. Deaths from infection increased by 167% year over year and accounted for 95% of excess deaths in 2020 over 2019. COVID-19 was the most common cause of death (68% of infection deaths, 33% of total deaths). The bulk of COVID-19 deaths [209/285 (73%)] occurred during the first COVID-19 wave, which roughly accounted for the increased mortality in 2020. Being a KT recipient was an independent risk factor for COVID-19 death | ||
| 520 | |a CONCLUSIONS: COVID-19 negatively impacted the incidence and prevalence of KRT, but the increase in KRT deaths was localized to the first wave of the pandemic. The increased annual mortality argues against COVID-19 accelerating the death of patients with short life expectancy and the temporal pattern of COVID-19 mortality suggests that appropriate healthcare may improve outcomes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a chronic kidney disease | |
| 650 | 4 | |a haemodialysis | |
| 650 | 4 | |a kidney replacement therapy | |
| 650 | 4 | |a kidney transplantation | |
| 650 | 4 | |a mortality | |
| 650 | 4 | |a peritoneal dialysis | |
| 700 | 1 | |a Aparicio-Madre, Manuel I |e verfasserin |4 aut | |
| 700 | 1 | |a Tornero-Molina, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández-Lucas, Milagros |e verfasserin |4 aut | |
| 700 | 1 | |a Paraiso-Cuevas, Vicente |e verfasserin |4 aut | |
| 700 | 1 | |a González-Parra, Emilio |e verfasserin |4 aut | |
| 700 | 1 | |a Del Río-Gallegos, Francisco |e verfasserin |4 aut | |
| 700 | 1 | |a Marques-Vidas, María |e verfasserin |4 aut | |
| 700 | 1 | |a Alcázar-Arroyo, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Martins-Muñoz, Judith |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez-Villanueva, Rafael |e verfasserin |4 aut | |
| 700 | 1 | |a Gil-Casares, Beatriz |e verfasserin |4 aut | |
| 700 | 1 | |a Gutiérrez-Martínez, Eduardo |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez-Rubio, María Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a Ortiz, Alberto |e verfasserin |4 aut | |
| 700 | 0 | |a REMER Committee |e verfasserin |4 aut | |
| 700 | 1 | |a Diezhandino, Maria Ángeles Goicoechea |e investigator |4 oth | |
| 700 | 1 | |a Ferrero, María Luisa Rodriguez |e investigator |4 oth | |
| 700 | 1 | |a Estébanez, Soraya Abad |e investigator |4 oth | |
| 700 | 1 | |a Lucas, Milagros Fernández |e investigator |4 oth | |
| 700 | 1 | |a Mendiola, Nuria Rodríguez |e investigator |4 oth | |
| 700 | 1 | |a Domínguez, Martha Díaz |e investigator |4 oth | |
| 700 | 1 | |a Triviño, Sandra Elias |e investigator |4 oth | |
| 700 | 1 | |a Vion, Victor Burguera |e investigator |4 oth | |
| 700 | 1 | |a Martín, Carlos Jiménez |e investigator |4 oth | |
| 700 | 1 | |a Rubio, Auxiliadora Bajo |e investigator |4 oth | |
| 700 | 1 | |a Gutiérrez, Rafael Selgas |e investigator |4 oth | |
| 700 | 1 | |a Melgar, Ángel Alonso |e investigator |4 oth | |
| 700 | 1 | |a Román, Laura Espinosa |e investigator |4 oth | |
| 700 | 1 | |a Pérez, José María Portolés |e investigator |4 oth | |
| 700 | 1 | |a Sobrino, Beatriz Sánchez |e investigator |4 oth | |
| 700 | 1 | |a Carratalá, Rosario Llópez |e investigator |4 oth | |
| 700 | 1 | |a Calvo, José Antonio Herrero |e investigator |4 oth | |
| 700 | 1 | |a Flores, Isabel Pérez |e investigator |4 oth | |
| 700 | 1 | |a Fructuoso, Ana Isabel Sánchez |e investigator |4 oth | |
| 700 | 1 | |a Caro-Espada, Paula Jara |e investigator |4 oth | |
| 700 | 1 | |a Solís, Elena Gutiérrez |e investigator |4 oth | |
| 700 | 1 | |a Martín-Cleary, Catalina |e investigator |4 oth | |
| 700 | 1 | |a Verde, Ana Ramos |e investigator |4 oth | |
| 700 | 1 | |a Pérez, Jesús Hernández |e investigator |4 oth | |
| 700 | 1 | |a Cuadrado, Guillermina Barril |e investigator |4 oth | |
| 700 | 1 | |a González, Martín Giorgi |e investigator |4 oth | |
| 700 | 1 | |a Perpén, Antonio Fernández |e investigator |4 oth | |
| 700 | 1 | |a Carro, Cristina Bernis |e investigator |4 oth | |
| 700 | 1 | |a Miguel, Patricia Martínez |e investigator |4 oth | |
| 700 | 1 | |a Barrio, María Fuensanta Moreno |e investigator |4 oth | |
| 700 | 1 | |a Bouarich, Hanane |e investigator |4 oth | |
| 700 | 1 | |a Fernández, María Pérez |e investigator |4 oth | |
| 700 | 1 | |a Vergara, Enrique Gruss |e investigator |4 oth | |
| 700 | 1 | |a Juárez, Gema María Fernández |e investigator |4 oth | |
| 700 | 1 | |a Valcarce, Eduardo Gallego |e investigator |4 oth | |
| 700 | 1 | |a Ribera, Ana Tato |e investigator |4 oth | |
| 700 | 1 | |a Berrón, Juan Carlos Herrero |e investigator |4 oth | |
| 700 | 1 | |a Nieto, María Teresa Naya |e investigator |4 oth | |
| 700 | 1 | |a Alcaraz, Alfonso Cubas |e investigator |4 oth | |
| 700 | 1 | |a Molina, Fernando Tornero |e investigator |4 oth | |
| 700 | 1 | |a Casanova, Beatriz Gil-Casares |e investigator |4 oth | |
| 700 | 1 | |a Estévez, Elda Besada |e investigator |4 oth | |
| 700 | 1 | |a Cuevas, Vicente Paraíso |e investigator |4 oth | |
| 700 | 1 | |a García, Jesús Benito |e investigator |4 oth | |
| 700 | 1 | |a Pérez, Alicia García |e investigator |4 oth | |
| 700 | 1 | |a Prestel, Valeria Sáiz |e investigator |4 oth | |
| 700 | 1 | |a Ortiz, Patricia de Sequera |e investigator |4 oth | |
| 700 | 1 | |a Carrillo, Rocío Echarri |e investigator |4 oth | |
| 700 | 1 | |a Ojanguren, M Covadonga Hevia |e investigator |4 oth | |
| 700 | 1 | |a Herrero, María Del Carmen Jiménez |e investigator |4 oth | |
| 700 | 1 | |a Alexandru, Simona |e investigator |4 oth | |
| 700 | 1 | |a Saico, Saúl Enrique Pampa |e investigator |4 oth | |
| 700 | 1 | |a Hernández, Rosa Sánchez |e investigator |4 oth | |
| 700 | 1 | |a González-Mariño, Rocío Zamora |e investigator |4 oth | |
| 700 | 1 | |a Jiménez, Laura Rodríguez-Osorio |e investigator |4 oth | |
| 700 | 1 | |a Gurpide, Beatriz Durá |e investigator |4 oth | |
| 700 | 1 | |a Cicero, Elisa Ruiz |e investigator |4 oth | |
| 700 | 1 | |a Sierra, Cristina Albarracín |e investigator |4 oth | |
| 700 | 1 | |a Lillo, Ramón Delgado |e investigator |4 oth | |
| 700 | 1 | |a Yagüe, María Delgado |e investigator |4 oth | |
| 700 | 1 | |a Alonso, D Jorge Valencia |e investigator |4 oth | |
| 700 | 1 | |a Gota Ángel, Raquel |e investigator |4 oth | |
| 700 | 1 | |a Guajardo, Aurelio Sanz |e investigator |4 oth | |
| 700 | 1 | |a Martín, Carlos Jiménez |e investigator |4 oth | |
| 700 | 1 | |a Pérez, Jesús Hernández |e investigator |4 oth | |
| 700 | 1 | |a Czerpak, Karina Ruth Furaz |e investigator |4 oth | |
| 700 | 1 | |a Abreu, Ángel Agustín Méndez |e investigator |4 oth | |
| 700 | 1 | |a Lorenzo, Ana Botella |e investigator |4 oth | |
| 700 | 1 | |a Sanz, Javier Naranjo |e investigator |4 oth | |
| 700 | 1 | |a Ares, María Teresa Villaverde |e investigator |4 oth | |
| 700 | 1 | |a Gasch, Sandra Castellano |e investigator |4 oth | |
| 700 | 1 | |a Rubio, María Del Pilar Martínez |e investigator |4 oth | |
| 700 | 1 | |a Villanueva, Patricia Nora Estrada |e investigator |4 oth | |
| 700 | 1 | |a Alvarado, José Ramón Berlanga |e investigator |4 oth | |
| 700 | 1 | |a Santos, Ana María Blanco |e investigator |4 oth | |
| 700 | 1 | |a Matías, Carmen Gámez |e investigator |4 oth | |
| 700 | 1 | |a Hernández, Pablo Mateos |e investigator |4 oth | |
| 700 | 1 | |a Sainz, Marta Sanz |e investigator |4 oth | |
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