The Cardiorenal Connection : Is Cardiac Output the Sole Determinant of Renal Dysfunction in Cirrhosis?
Copyright © 2022 by The American College of Gastroenterology..
ABSTRACT: Hemodynamic abnormalities are the hallmarks of advanced cirrhosis. An increased cardiac output maintains hemodynamic stability until the very late stage of cirrhosis, when the cardiac output starts to fall, which has been attributed to the development of renal dysfunction in these patients. The study by Daniesen showed that cardiac output was increased rather than decreased in patients with hepatorenal syndrome-acute kidney injury, potentially conflicting with previous understanding. It is possible that the authors were only assessing 1 aspect of cardiac dysfunction in a group of patients who were not at the very end stage of cirrhosis. Their unexpected findings will certainly stimulate further research into the role of cardiac dysfunction in the pathogenesis of acute kidney injury in cirrhosis.
| Errataetall: |
CommentOn: Am J Gastroenterol. 2022 Aug 1;117(8):1269-1278. - PMID 35916685 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:117 |
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| Enthalten in: |
The American journal of gastroenterology - 117(2022), 8 vom: 01. Aug., Seite 1242-1243 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wong, Florence [VerfasserIn] |
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Date Completed 08.08.2022 Date Revised 18.07.2023 published: Print-Electronic CommentOn: Am J Gastroenterol. 2022 Aug 1;117(8):1269-1278. - PMID 35916685 Citation Status MEDLINE |
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| doi: |
10.14309/ajg.0000000000001848 |
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NLM344460304 |
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| 500 | |a Citation Status MEDLINE | ||
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| 520 | |a ABSTRACT: Hemodynamic abnormalities are the hallmarks of advanced cirrhosis. An increased cardiac output maintains hemodynamic stability until the very late stage of cirrhosis, when the cardiac output starts to fall, which has been attributed to the development of renal dysfunction in these patients. The study by Daniesen showed that cardiac output was increased rather than decreased in patients with hepatorenal syndrome-acute kidney injury, potentially conflicting with previous understanding. It is possible that the authors were only assessing 1 aspect of cardiac dysfunction in a group of patients who were not at the very end stage of cirrhosis. Their unexpected findings will certainly stimulate further research into the role of cardiac dysfunction in the pathogenesis of acute kidney injury in cirrhosis | ||
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