Beta-Secretase-1 Antisense RNA Is Associated with Vascular Ageing and Atherosclerotic Cardiovascular Disease
The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)..
BACKGROUND: The noncoding antisense transcript for β-secretase-1 (BACE1-AS) is a long noncoding RNA with a pivotal role in the regulation of amyloid-β (Aβ). We aimed to explore the clinical value of BACE1-AS expression in atherosclerotic cardiovascular disease (ASCVD).
METHODS: Expression of BACE1-AS and its target, β-secretase 1 (BACE1) mRNA, was measured in peripheral blood mononuclear cells derived from 434 individuals (259 without established ASCVD [non-CVD], 90 with stable coronary artery disease [CAD], and 85 with acute coronary syndrome). Intima-media thickness and atheromatous plaques evaluated by ultrasonography, as well as arterial wave reflections and pulse wave velocity, were measured as markers of subclinical ASCVD. Patients were followed for a median of 52 months for major adverse cardiovascular events (MACE).
RESULTS: In the cross-sectional arm, BACE1-AS expression correlated with BACE1 expression (r = 0.396, p < 0.001) and marginally with Aβ1-40 levels in plasma (r = 0.141, p = 0.008). Higher BACE1-AS was associated with higher estimated CVD risk assessed by HeartScore for non-CVD subjects and by European Society of Cardiology clinical criteria for the total population (p < 0.05 for both). BACE1-AS was associated with higher prevalence of CAD (odds ratio [OR] = 1.85, 95% confidence interval [CI]: 1.37-2.5), multivessel CAD (OR = 1.36, 95% CI: 1.06-1.75), and with higher number of diseased vascular beds (OR = 1.31, 95% CI: 1.07-1.61, for multiple diseased vascular beds) after multivariable adjustment for traditional cardiovascular risk factors. In the prospective arm, BACE1-AS was an independent predictor of MACE in high cardiovascular risk patients (adjusted hazard ratio = 1.86 per ascending tertile, 95% CI: 1.011-3.43, p = 0.046).
CONCLUSION: BACE1-AS is associated with the incidence and severity of ASCVD.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:122 |
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| Enthalten in: |
Thrombosis and haemostasis - 122(2022), 11 vom: 16. Nov., Seite 1932-1942 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bampatsias, Dimitrios [VerfasserIn] |
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| Links: |
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| Themen: |
Amyloid Precursor Protein Secretases |
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| Anmerkungen: |
Date Completed 04.11.2022 Date Revised 04.11.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1055/a-1914-2094 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM344355888 |
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| 100 | 1 | |a Bampatsias, Dimitrios |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Beta-Secretase-1 Antisense RNA Is Associated with Vascular Ageing and Atherosclerotic Cardiovascular Disease |
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| 500 | |a Date Completed 04.11.2022 | ||
| 500 | |a Date Revised 04.11.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). | ||
| 520 | |a BACKGROUND: The noncoding antisense transcript for β-secretase-1 (BACE1-AS) is a long noncoding RNA with a pivotal role in the regulation of amyloid-β (Aβ). We aimed to explore the clinical value of BACE1-AS expression in atherosclerotic cardiovascular disease (ASCVD) | ||
| 520 | |a METHODS: Expression of BACE1-AS and its target, β-secretase 1 (BACE1) mRNA, was measured in peripheral blood mononuclear cells derived from 434 individuals (259 without established ASCVD [non-CVD], 90 with stable coronary artery disease [CAD], and 85 with acute coronary syndrome). Intima-media thickness and atheromatous plaques evaluated by ultrasonography, as well as arterial wave reflections and pulse wave velocity, were measured as markers of subclinical ASCVD. Patients were followed for a median of 52 months for major adverse cardiovascular events (MACE) | ||
| 520 | |a RESULTS: In the cross-sectional arm, BACE1-AS expression correlated with BACE1 expression (r = 0.396, p < 0.001) and marginally with Aβ1-40 levels in plasma (r = 0.141, p = 0.008). Higher BACE1-AS was associated with higher estimated CVD risk assessed by HeartScore for non-CVD subjects and by European Society of Cardiology clinical criteria for the total population (p < 0.05 for both). BACE1-AS was associated with higher prevalence of CAD (odds ratio [OR] = 1.85, 95% confidence interval [CI]: 1.37-2.5), multivessel CAD (OR = 1.36, 95% CI: 1.06-1.75), and with higher number of diseased vascular beds (OR = 1.31, 95% CI: 1.07-1.61, for multiple diseased vascular beds) after multivariable adjustment for traditional cardiovascular risk factors. In the prospective arm, BACE1-AS was an independent predictor of MACE in high cardiovascular risk patients (adjusted hazard ratio = 1.86 per ascending tertile, 95% CI: 1.011-3.43, p = 0.046) | ||
| 520 | |a CONCLUSION: BACE1-AS is associated with the incidence and severity of ASCVD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Amyloid Precursor Protein Secretases |2 NLM | |
| 650 | 7 | |a EC 3.4.- |2 NLM | |
| 650 | 7 | |a Aspartic Acid Endopeptidases |2 NLM | |
| 650 | 7 | |a EC 3.4.23.- |2 NLM | |
| 650 | 7 | |a RNA, Antisense |2 NLM | |
| 650 | 7 | |a BACE1-AS long non-coding RNA, human |2 NLM | |
| 650 | 7 | |a RNA, Long Noncoding |2 NLM | |
| 700 | 1 | |a Mavroeidis, Ioannis |e verfasserin |4 aut | |
| 700 | 1 | |a Tual-Chalot, Simon |e verfasserin |4 aut | |
| 700 | 1 | |a Vlachogiannis, Nikolaos I |e verfasserin |4 aut | |
| 700 | 1 | |a Bonini, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Sachse, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Mavraganis, Georgios |e verfasserin |4 aut | |
| 700 | 1 | |a Mareti, Alexia |e verfasserin |4 aut | |
| 700 | 1 | |a Kritsioti, Chrysoula |e verfasserin |4 aut | |
| 700 | 1 | |a Laina, Ageliki |e verfasserin |4 aut | |
| 700 | 1 | |a Delialis, Dimitrios |e verfasserin |4 aut | |
| 700 | 1 | |a Ciliberti, Giorgia |e verfasserin |4 aut | |
| 700 | 1 | |a Sopova, Kateryna |e verfasserin |4 aut | |
| 700 | 1 | |a Gatsiou, Aikaterini |e verfasserin |4 aut | |
| 700 | 1 | |a Martelli, Fabio |e verfasserin |4 aut | |
| 700 | 1 | |a Georgiopoulos, Georgios |e verfasserin |4 aut | |
| 700 | 1 | |a Stellos, Konstantinos |e verfasserin |4 aut | |
| 700 | 1 | |a Stamatelopoulos, Kimon |e verfasserin |4 aut | |
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