Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection : A Population-Based Longitudinal Study
© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
In this population-based cohort of 7538 adults, combined immunoglobulin (Ig) G, IgA, and IgM (IgG/A/M) anti-spike titers measured after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination were predictive of protection against breakthrough SARS-CoV-2 infection. Discrimination was significantly improved by adjustment for factors influencing risk of SARS-CoV-2 exposure, including household overcrowding, public transport use, and visits to indoor public places. Anti-spike IgG/A/M titers showed positive correlation with neutralizing antibody titers (rs = 0.80 [95% confidence interval, .72-.86]; P < .001) and S peptide-stimulated interferon-γ concentrations (rs = 0.31 [.13-.47]; P < .001).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:226 |
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| Enthalten in: |
The Journal of infectious diseases - 226(2022), 11 vom: 28. Nov., Seite 1903-1908 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Vivaldi, Giulia [VerfasserIn] |
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| Links: |
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| Themen: |
Antibodies, Viral |
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| Anmerkungen: |
Date Completed 30.11.2022 Date Revised 30.12.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/infdis/jiac321 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a In this population-based cohort of 7538 adults, combined immunoglobulin (Ig) G, IgA, and IgM (IgG/A/M) anti-spike titers measured after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination were predictive of protection against breakthrough SARS-CoV-2 infection. Discrimination was significantly improved by adjustment for factors influencing risk of SARS-CoV-2 exposure, including household overcrowding, public transport use, and visits to indoor public places. Anti-spike IgG/A/M titers showed positive correlation with neutralizing antibody titers (rs = 0.80 [95% confidence interval, .72-.86]; P < .001) and S peptide-stimulated interferon-γ concentrations (rs = 0.31 [.13-.47]; P < .001) | ||
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| 700 | 1 | |a Holt, Hayley |e verfasserin |4 aut | |
| 700 | 1 | |a Perdek, Natalia |e verfasserin |4 aut | |
| 700 | 1 | |a Talaei, Mohammad |e verfasserin |4 aut | |
| 700 | 1 | |a Tydeman, Florence |e verfasserin |4 aut | |
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| 700 | 1 | |a Cai, Weigang |e verfasserin |4 aut | |
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| 700 | 1 | |a McKnight, Áine |e verfasserin |4 aut | |
| 700 | 1 | |a Shaheen, Seif O |e verfasserin |4 aut | |
| 700 | 1 | |a Richter, Alex G |e verfasserin |4 aut | |
| 700 | 1 | |a Martineau, Adrian R |e verfasserin |4 aut | |
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