Interleukin 15 in murine models of colitis
© 2022 American Association for Anatomy..
Inflammatory bowel diseases (IBDs) are characterized by abnormal, non-antigen specific chronic inflammation of unknown etiology. Genome-wide association studies show that many IBD genetic susceptibility loci map to immune function genes and compelling evidence indicate that environmental factors play a critical role in IBD pathogenesis. Clinical and experimental evidence implicate the pro-inflammatory cytokine IL-15 in the pathogenesis of IBD. IL-15 and IL-15α expression is increased in the inflamed mucosa of IBD patients. IL-15 contributes to the maintenance of different cell subsets in the intestinal mucosa. However, very few studies have addressed the role of IL-15 in pre-clinical models of colitis. In this study, we use three well-characterized models of experimental colitis to determine the contribution of IL-15 to pathological intestinal inflammation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:306 |
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| Enthalten in: |
Anatomical record (Hoboken, N.J. : 2007) - 306(2023), 5 vom: 10. Mai, Seite 1111-1130 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kautzman, Alicia Molina [VerfasserIn] |
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| Links: |
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| Themen: |
Colitis |
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| Anmerkungen: |
Date Completed 14.04.2023 Date Revised 17.04.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/ar.25044 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM344196143 |
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| 520 | |a © 2022 American Association for Anatomy. | ||
| 520 | |a Inflammatory bowel diseases (IBDs) are characterized by abnormal, non-antigen specific chronic inflammation of unknown etiology. Genome-wide association studies show that many IBD genetic susceptibility loci map to immune function genes and compelling evidence indicate that environmental factors play a critical role in IBD pathogenesis. Clinical and experimental evidence implicate the pro-inflammatory cytokine IL-15 in the pathogenesis of IBD. IL-15 and IL-15α expression is increased in the inflamed mucosa of IBD patients. IL-15 contributes to the maintenance of different cell subsets in the intestinal mucosa. However, very few studies have addressed the role of IL-15 in pre-clinical models of colitis. In this study, we use three well-characterized models of experimental colitis to determine the contribution of IL-15 to pathological intestinal inflammation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a IL-15 | |
| 650 | 4 | |a Salmonella | |
| 650 | 4 | |a colitis | |
| 650 | 7 | |a Interleukin-15 |2 NLM | |
| 700 | 1 | |a Mobulakani, Jeanne Masunga Faida |e verfasserin |4 aut | |
| 700 | 1 | |a Marrero Cofino, Gisela |e verfasserin |4 aut | |
| 700 | 1 | |a Quenum, Akouavi Julite Irmine |e verfasserin |4 aut | |
| 700 | 1 | |a Cayarga, Anny Armas |e verfasserin |4 aut | |
| 700 | 1 | |a Asselin, Claude |e verfasserin |4 aut | |
| 700 | 1 | |a Fortier, Louis-Charles |e verfasserin |4 aut | |
| 700 | 1 | |a Ilangumaran, Subburaj |e verfasserin |4 aut | |
| 700 | 1 | |a Menendez, Alfredo |e verfasserin |4 aut | |
| 700 | 1 | |a Ramanathan, Sheela |e verfasserin |4 aut | |
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