Neurological Disease Associated with Chikungunya in Indonesia
Chikungunya virus (CHIKV) is recognized but rarely considered as a cause of central nervous system infection in endemic areas. A total of 244 patients with acute meningoencephalitis in Indonesia were retrospectively tested to identify whether any CHIKV infection was associated with neurological manifestations, especially in provinces known for CHIKV endemicity. Cerebrospinal fluid (CSF) and blood specimens were tested using CHIKV-specific real-time reverse transcription polymerase chain reaction and IgM ELISA, alongside a panel of neurotropic viruses. We report four cases of suspected or confirmed CHIKV-associated neurological disease, including CHIKV RNA detection in CSF of one patient and in acute serum of another, and CHIKV IgM in CSF of three patients and in serum of a fourth. In conclusion, CHIKV should be considered as a cause of neurologic disease in endemic areas and especially during outbreaks, in addition to the more common arboviral diseases such as dengue and Japanese encephalitis viruses.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:107 |
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| Enthalten in: |
The American journal of tropical medicine and hygiene - 107(2022), 2 vom: 17. Aug., Seite 291-295 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Myint, Khin S A [VerfasserIn] |
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| Links: |
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| Themen: |
Immunoglobulin M |
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| Anmerkungen: |
Date Completed 04.09.2023 Date Revised 05.09.2023 published: Electronic-Print Citation Status MEDLINE |
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| doi: |
10.4269/ajtmh.22-0050 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM344152154 |
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| 100 | 1 | |a Myint, Khin S A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Neurological Disease Associated with Chikungunya in Indonesia |
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| 500 | |a Date Revised 05.09.2023 | ||
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Chikungunya virus (CHIKV) is recognized but rarely considered as a cause of central nervous system infection in endemic areas. A total of 244 patients with acute meningoencephalitis in Indonesia were retrospectively tested to identify whether any CHIKV infection was associated with neurological manifestations, especially in provinces known for CHIKV endemicity. Cerebrospinal fluid (CSF) and blood specimens were tested using CHIKV-specific real-time reverse transcription polymerase chain reaction and IgM ELISA, alongside a panel of neurotropic viruses. We report four cases of suspected or confirmed CHIKV-associated neurological disease, including CHIKV RNA detection in CSF of one patient and in acute serum of another, and CHIKV IgM in CSF of three patients and in serum of a fourth. In conclusion, CHIKV should be considered as a cause of neurologic disease in endemic areas and especially during outbreaks, in addition to the more common arboviral diseases such as dengue and Japanese encephalitis viruses | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 650 | 7 | |a Immunoglobulin M |2 NLM | |
| 700 | 1 | |a Mawuntu, Arthur H P |e verfasserin |4 aut | |
| 700 | 1 | |a Haryanto, Sotianingsih |e verfasserin |4 aut | |
| 700 | 1 | |a Imran, Darma |e verfasserin |4 aut | |
| 700 | 1 | |a Dian, Sofiati |e verfasserin |4 aut | |
| 700 | 1 | |a Dewi, Yora P |e verfasserin |4 aut | |
| 700 | 1 | |a Ganiem, Ahmad R |e verfasserin |4 aut | |
| 700 | 1 | |a Anggreani, Riane |e verfasserin |4 aut | |
| 700 | 1 | |a Iskandar, Mirna M |e verfasserin |4 aut | |
| 700 | 1 | |a Bernadus, Janno B B |e verfasserin |4 aut | |
| 700 | 1 | |a Maharani, Kartika |e verfasserin |4 aut | |
| 700 | 1 | |a Susanto, David |e verfasserin |4 aut | |
| 700 | 1 | |a Estiasari, Riwanti |e verfasserin |4 aut | |
| 700 | 1 | |a Dewi, Hasna |e verfasserin |4 aut | |
| 700 | 1 | |a Kristiani, Amanda |e verfasserin |4 aut | |
| 700 | 1 | |a Gaghiwu, Lidia |e verfasserin |4 aut | |
| 700 | 1 | |a Johar, Edison |e verfasserin |4 aut | |
| 700 | 1 | |a Yudhaputri, Frilasita A |e verfasserin |4 aut | |
| 700 | 1 | |a Antonjaya, Ungke |e verfasserin |4 aut | |
| 700 | 1 | |a Ledermann, Jeremy P |e verfasserin |4 aut | |
| 700 | 1 | |a van Crevel, Reinout |e verfasserin |4 aut | |
| 700 | 1 | |a Hamers, Raph L |e verfasserin |4 aut | |
| 700 | 1 | |a Powers, Ann M |e verfasserin |4 aut | |
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