Mechanically strong and on-demand dissoluble chitosan hydrogels for wound dressing applications
Copyright © 2022 Elsevier Ltd. All rights reserved..
Physical hydrogels of pure chitosan preserve the natural properties of chitosan, and therefore are ideal candidates for wound dressing applications, however, their poor mechanical strength severely limits their application. In addition, chitosan dressings tend to adhere to the wounds, making their change difficult. Here physical hydrogels of pure chitosan were prepared by first dissolving chitosan in an alkaline aqueous solution, followed by thermal gelling and solvent change. The gels exhibited better mechanical properties than the gels prepared previously. They were soluble in diluted acetic acid, making them on-demand dissoluble. When used as wound dressing and changed by mechanical debridement, the gels achieved a faster wound closure than gauze. An even faster wound closure was achieved when they were changed by dissolution with acetic acid solution. Besides a faster healing, the on-demand dissoluble dressing could also reduce the formation of scars and reestablish the normal anatomy and function of the skin.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:294 |
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| Enthalten in: |
Carbohydrate polymers - 294(2022) vom: 15. Okt., Seite 119774 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Luo, Ying [VerfasserIn] |
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| Links: |
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| Themen: |
9012-76-4 |
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| Anmerkungen: |
Date Completed 26.07.2022 Date Revised 26.07.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.carbpol.2022.119774 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Physical hydrogels of pure chitosan preserve the natural properties of chitosan, and therefore are ideal candidates for wound dressing applications, however, their poor mechanical strength severely limits their application. In addition, chitosan dressings tend to adhere to the wounds, making their change difficult. Here physical hydrogels of pure chitosan were prepared by first dissolving chitosan in an alkaline aqueous solution, followed by thermal gelling and solvent change. The gels exhibited better mechanical properties than the gels prepared previously. They were soluble in diluted acetic acid, making them on-demand dissoluble. When used as wound dressing and changed by mechanical debridement, the gels achieved a faster wound closure than gauze. An even faster wound closure was achieved when they were changed by dissolution with acetic acid solution. Besides a faster healing, the on-demand dissoluble dressing could also reduce the formation of scars and reestablish the normal anatomy and function of the skin | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Chitosan | |
| 650 | 4 | |a Mechanical properties | |
| 650 | 4 | |a On-demand dissoluble | |
| 650 | 4 | |a Physical hydrogels | |
| 650 | 4 | |a Wound dressings | |
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| 700 | 1 | |a Guan, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yongjun |e verfasserin |4 aut | |
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