High serum ferritin alone as a predictor of mortality and hemophagocytic lymphohistiocytosis
© 2021 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd..
We report here utility of high serum ferritin alone as a predictor of mortality and diagnosis of hemophagocytic lymphohistiocytosis (HLH). We compared mortality in patients with high serum ferritin >5000 ng/mL versus <5000 ng/mL and looked for presence of HLH. Mortality was significantly higher (P-value .0048) in patients with serum ferritin levels >5000 ug/dL. Of 21 patients with high serum ferritin, a median of three criteria were fulfilled to diagnose HLH. All patients had features of immune-activation, and 76.2% patients had features of immune-pathology favoring diagnosis of HLH. Serum ferritin can aid in prediction of mortality and help in the early diagnosis of HLH.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2 |
|---|---|
| Enthalten in: |
EJHaem - 2(2021), 1 vom: 11. Feb., Seite 136-138 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Kohli, Shruti [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Ferritin |
|---|
| Anmerkungen: |
Date Revised 19.07.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1002/jha2.153 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM343663112 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM343663112 | ||
| 003 | DE-627 | ||
| 005 | 20231226020956.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/jha2.153 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1145.xml |
| 035 | |a (DE-627)NLM343663112 | ||
| 035 | |a (NLM)35846094 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kohli, Shruti |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a High serum ferritin alone as a predictor of mortality and hemophagocytic lymphohistiocytosis |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 19.07.2022 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2021 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. | ||
| 520 | |a We report here utility of high serum ferritin alone as a predictor of mortality and diagnosis of hemophagocytic lymphohistiocytosis (HLH). We compared mortality in patients with high serum ferritin >5000 ng/mL versus <5000 ng/mL and looked for presence of HLH. Mortality was significantly higher (P-value .0048) in patients with serum ferritin levels >5000 ug/dL. Of 21 patients with high serum ferritin, a median of three criteria were fulfilled to diagnose HLH. All patients had features of immune-activation, and 76.2% patients had features of immune-pathology favoring diagnosis of HLH. Serum ferritin can aid in prediction of mortality and help in the early diagnosis of HLH | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ferritin | |
| 650 | 4 | |a hemophagocytic lympho histiocytosis | |
| 650 | 4 | |a mortality | |
| 700 | 1 | |a Chadha, Ritu |e verfasserin |4 aut | |
| 700 | 1 | |a Rastogi, Neha |e verfasserin |4 aut | |
| 700 | 1 | |a Yadav, Satya Prakash |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t EJHaem |d 2020 |g 2(2021), 1 vom: 11. Feb., Seite 136-138 |w (DE-627)NLM314118454 |x 2688-6146 |7 nnns |
| 773 | 1 | 8 | |g volume:2 |g year:2021 |g number:1 |g day:11 |g month:02 |g pages:136-138 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/jha2.153 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 2 |j 2021 |e 1 |b 11 |c 02 |h 136-138 | ||