Usefulness of ethiodized oil and gelatin sponge particles for delaying the washout of indocyanine green from the liver in swine
© 2022. The Author(s)..
PURPOSE: To assess the effect of ethiodized oil (EO) and gelatin sponge particles (GS) on delaying the washout of indocyanine green (ICG) from the liver in swine.
METHODS: Fifteen swine were divided into 3 groups: injection of a mixture of ICG and water-soluble contrast medium (CM) followed by embolization with GS (group A), injection of a mixture of ICG and EO (group B) and injection of a mixture of ICG and EO followed by embolization with GS (group C). The liver surface was observed using an infrared camera system during and at 1, 2, 3, and 6 h after the procedure to measure ICG contrast. Livers were removed at 6 h for histopathological examination.
RESULTS: The contrast ratio between injected and non-injected regions at 6 h was 1.45 ± 0.44 in group A, 1.89 ± 0.37 in group B, and 3.62 ± 0.76 in group C. The contrast ratio in group C was significantly greater than that in groups A and B (P = 0.032 and 0.033, respectively).
CONCLUSIONS: EO and GS delayed the washout of ICG from the liver in swine and may extend intraoperative navigation in clinical use. Indocyanine green (ICG) mixed with ethiodized oil (EO) was injected into the left hepatic artery in swine, and the artery was embolized with gelatin sponge particles (GS). We confirmed that ICG remained in the liver parenchyma up to 6 h after the procedure. EO and GS delayed the washout of ICG from the liver in swine.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
Japanese journal of radiology - 40(2022), 12 vom: 16. Dez., Seite 1300-1306 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tanaka, Ryota [VerfasserIn] |
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| Links: |
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| Themen: |
8008-53-5 |
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| Anmerkungen: |
Date Completed 06.12.2022 Date Revised 07.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s11604-022-01315-9 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM343616947 |
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| 100 | 1 | |a Tanaka, Ryota |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Usefulness of ethiodized oil and gelatin sponge particles for delaying the washout of indocyanine green from the liver in swine |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Revised 07.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. The Author(s). | ||
| 520 | |a PURPOSE: To assess the effect of ethiodized oil (EO) and gelatin sponge particles (GS) on delaying the washout of indocyanine green (ICG) from the liver in swine | ||
| 520 | |a METHODS: Fifteen swine were divided into 3 groups: injection of a mixture of ICG and water-soluble contrast medium (CM) followed by embolization with GS (group A), injection of a mixture of ICG and EO (group B) and injection of a mixture of ICG and EO followed by embolization with GS (group C). The liver surface was observed using an infrared camera system during and at 1, 2, 3, and 6 h after the procedure to measure ICG contrast. Livers were removed at 6 h for histopathological examination | ||
| 520 | |a RESULTS: The contrast ratio between injected and non-injected regions at 6 h was 1.45 ± 0.44 in group A, 1.89 ± 0.37 in group B, and 3.62 ± 0.76 in group C. The contrast ratio in group C was significantly greater than that in groups A and B (P = 0.032 and 0.033, respectively) | ||
| 520 | |a CONCLUSIONS: EO and GS delayed the washout of ICG from the liver in swine and may extend intraoperative navigation in clinical use. Indocyanine green (ICG) mixed with ethiodized oil (EO) was injected into the left hepatic artery in swine, and the artery was embolized with gelatin sponge particles (GS). We confirmed that ICG remained in the liver parenchyma up to 6 h after the procedure. EO and GS delayed the washout of ICG from the liver in swine | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Ethiodized oil | |
| 650 | 4 | |a Gelatin sponge particles | |
| 650 | 4 | |a Indocyanine green | |
| 650 | 4 | |a Infrared camera system | |
| 650 | 4 | |a Intraoperative navigation | |
| 650 | 7 | |a Ethiodized Oil |2 NLM | |
| 650 | 7 | |a 8008-53-5 |2 NLM | |
| 650 | 7 | |a Indocyanine Green |2 NLM | |
| 650 | 7 | |a IX6J1063HV |2 NLM | |
| 650 | 7 | |a Gelatin |2 NLM | |
| 650 | 7 | |a 9000-70-8 |2 NLM | |
| 700 | 1 | |a Sonomura, Tetsuo |e verfasserin |4 aut | |
| 700 | 1 | |a Ueno, Masaki |e verfasserin |4 aut | |
| 700 | 1 | |a Koike, Masataka |e verfasserin |4 aut | |
| 700 | 1 | |a Makitani, Ayano |e verfasserin |4 aut | |
| 700 | 1 | |a Sato, Hirotatsu |e verfasserin |4 aut | |
| 700 | 1 | |a Fukuda, Kodai |e verfasserin |4 aut | |
| 700 | 1 | |a Higashino, Nobuyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Ikoma, Akira |e verfasserin |4 aut | |
| 700 | 1 | |a Murata, Shin-Ichi |e verfasserin |4 aut | |
| 700 | 1 | |a Minamiguchi, Hiroki |e verfasserin |4 aut | |
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