Mechanistic insights and implications of FOXO-SNAI interplay
© 2022 Wiley Periodicals LLC..
Autophagy promotes both health and disease, depending on tissue types and genetic contexts, yet the regulatory mechanism remain incompletely understood. Our recent publication has uncovered a coherent FOXO-SNAI feed-forward loop in autophagy, which is evolutionarily conserved from Drosophila to human. In addition, it's revealed that DNA binding plays a critical role in intracellular localization of nucleocytoplasmic shuttling proteins. Based on these findings, herein we further integrate mechanistic insights of FOXO-SNAI regulatory interplay in autophagy and unravel the potential link of FOXO-induced autophagy with SNAI in diseases. Besides, the generality of DNA-retention mechanism on transcription factor nuclear localization is illustrated with wide-ranging discussion, and more functions potentially regulated by FOXO-SNAI feedforward loop are provided. Elucidation of these unsolved paradigms will expand the understanding of FOXO-SNAI interplay and facilitate the development of new therapeutics targeting FOXO-SNAI axis in diseases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:44 |
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| Enthalten in: |
BioEssays : news and reviews in molecular, cellular and developmental biology - 44(2022), 9 vom: 26. Sept., Seite e2200070 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Guo, Xiaowei [VerfasserIn] |
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| Links: |
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| Themen: |
Autophagy |
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| Anmerkungen: |
Date Completed 24.08.2022 Date Revised 19.09.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/bies.202200070 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM343523388 |
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| 520 | |a © 2022 Wiley Periodicals LLC. | ||
| 520 | |a Autophagy promotes both health and disease, depending on tissue types and genetic contexts, yet the regulatory mechanism remain incompletely understood. Our recent publication has uncovered a coherent FOXO-SNAI feed-forward loop in autophagy, which is evolutionarily conserved from Drosophila to human. In addition, it's revealed that DNA binding plays a critical role in intracellular localization of nucleocytoplasmic shuttling proteins. Based on these findings, herein we further integrate mechanistic insights of FOXO-SNAI regulatory interplay in autophagy and unravel the potential link of FOXO-induced autophagy with SNAI in diseases. Besides, the generality of DNA-retention mechanism on transcription factor nuclear localization is illustrated with wide-ranging discussion, and more functions potentially regulated by FOXO-SNAI feedforward loop are provided. Elucidation of these unsolved paradigms will expand the understanding of FOXO-SNAI interplay and facilitate the development of new therapeutics targeting FOXO-SNAI axis in diseases | ||
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| 700 | 1 | |a Peng, Kai |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Xianjue |e verfasserin |4 aut | |
| 700 | 1 | |a Xue, Lei |e verfasserin |4 aut | |
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